A total synthesis method for protosappanin A, which is a complex natural product with many biological activities, was developed with 6 linear steps. Dibenzo[b,d]oxepinones as the key intermediates of the synthetic route were prepared by a palladium-catalyzed ortho C-H activation/C-C cyclization under microwave irradiation. 25 derivatives of protosappanin A were obtained.

No abstract

A visible-light-induced palladium-catalyzed cascade reaction was developed by etherification/C–C coupling cyclization of α-bromoacetophenones with phenols.