It has been suggested that the inhibition of gastric secretion by intraduodenal fat is a vagal phenomenon in man. Selective and highly selective vagotomy, by preserving this reflex, could offer advantages over truncal vagal section. This paper reports the effect of intraduodenal fat on pentagastrin‐stimulated gastric secretion in duodenal ulcer patients before and after truncal vagotomy. Marked inhibition of gastric secretion occurred in all the patients. In the postoperative group gastric secretion was almost totally abolished following fat infusion despite the absence of an abdominal vagal supply. The results suggest that inhibition of gastric secretion by intraduodenal fat is mediated by a nonvagal mechanism in man; from this point of view, therefore, there is little advantage in attempting to preserve the nerve‐supply to the duodenum at vagotomy.

The incidence of oesophagitis has been determined in 108 patients with sliding hiatus hernias using endoscopic, histological, and radiological criteria. Particular consideration has been given to the relationship between inflammatory disease and clinical symptoms. All the patients were attending a thoracic surgical clinic and the spectrum of disease encountered was fairly severe; over half of the cases had established strictures when first seen. The incidence of oesophagitis based on endoscopic evidence was 76-9%. while inflammatory change was noted on biopsy in 56 2% and at barium swallow in 58-3% of the patients. Oesophagoscopy proved to be the most satisfactory method of assessment; biopsy specimens were either inadequate or correlated poorly with other criteria while barium swallow was of diagnostic value only in severe oesophagitis. The main symptoms were pain, heartburn with regurgitation, dysphagia, and bleeding. Dysphagia was common due to the preponderance of patients with strictures, while obvious bleeding was very uncommon. Endoscopic oesophagitis was found in 75% of the patients with specific retrosternal pain and in 600O, of those with heartburn and regurgitation. The inability to equate heartburn with oesophagitis is emphasized. The incidence of inflammatory change in patients with dysphagia was 8722% ; nearly all the cases in this group showed stricture formation.Gastro-oesophageal reflux occurs in most patients with symptomatic hiatus hernia and may produce an inflammatory reaction of varying severity in the lower oesophagus. There is no agreement, however, on the frequency with which this reaction occurs nor on the influence it may have on clinical symptoms. In the past, many of the symptoms in hiatus hernia patients have been loosely attributed to reflux oesophagitis without adequate objective evidence. This study was undertaken firstly to determine the incidence of

Oesophageal resection with oesophagogastric anastomosis is said to be followed by severe oesophagitis. Little

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