Inefficient or poorly planned waste management systems are a burden to society and economy. For example, excessively long waste transportation routes can have a negative impact on a large share of the population. This is exacerbated by the rapid urbanization happening worldwide and in developing countries. Sustainability issues should be accounted for at every stage of decision making, from strategic to daily operations. In this paper, we propose a multiobjective optimization model to design a cost-effective waste management supply chain, while considering sustainability issues such as land-use and public health impacts. The model is applied to a case study in Pathum Thani (Thailand) to provide managerial insights.