Objectives: To find out the effect of bacterial urinary tract infection on prostate specific antigen levels in patients serum the secreted by the prostate gland. Methodology: the present study was carried out on (113) patients suffering of urinary tract infection attending to Al-Sader Medical City and Al-Hakeem General Hospital in in Al Najaf governorate and Forty apparently healthy control males. Their ages ranged between (36-55) years, the period of study was in October 2012 to June 2013.With a examined urine analysis, urine culture on media and measure prostate specific antigen levels in patients serum. Data was analyzed using SPSS 17 for the analysis purpose of the data ANOVA test was used with the extraction of value LSD. Results: Our findings were revealed high level of total prostate specific antigen in patients serum of urinary tract infection with positive culture (28.9%) and the absence of a rise in the level of total prostate specific antigen in patients serum with negative culture and apparently healthy control group, increasing in the normal levels of prostate-specific antigen in serum is associated with to increasing in age. The study showed that E. coli is the most common bacteria which is responsible for UTIs Conclusion: bacterial urinary tract infection in men effect on total prostate specific antigen level, secreted by the prostate gland. The level of total prostate specific antigen increases with increasing age. Recommendations: The study recommends the rapid diagnosis and treatment of urinary tract infection to avoid the complexity and the effect on the prostate gland , measuring the prostate specific antigen level before and after treatment.

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