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In this study, we focus on improving the efficiency and accuracy of nonrigid multi-modality registration of medical images. In this regard, we analyze the potentials of using the point similarity measurement approach as an alternative to global computation of mutual information (MI), which is still the most renown multi-modality similarity measure. The improvement capabilities are illustrated using the popular B-spline transformation model. The proposed solution is a combination of three related improvements of the most straightforward implementation, i.e., efficient computation of the voxel displacement field, local estimation of similarity and usage of a static image intensity dependence estimate. Five image registration prototypes were implemented to show contribution and dependence of the proposed improvements. When all the proposed improvements are applied, a significant reduction of computational cost and increased accuracy are obtained. The concept offers additional improvement opportunities by incorporating prior knowledge and machine learning techniques into the static intensity dependence estimation.