Herbal drugs have been used around the world since ancient times. The effectiveness of herbal drugs depends on their active constituents such as phenolic compounds, flavonoids, terpenoids, and tannins. These compounds were proven to show many therapeutic activities such as anti-inflammatory, antimicrobial and anticancer. However, they have many drawbacks restricting their applications and therapeutic outcomes such as low absorption due to their inability to cross the lipid membrane of the cell. Therefore, they have low bioavailability and efficacy. The nanotechnology is a cutting-edge science that might give a new hope to revitalize the use of herbal drugs. Nano-carrier systems are reported to potentiate the action of herbal drugs, due to their ability to improve their bioavailability. Moreover, herbal nano-medicine could be designed with a surface decoration to be targeted to the effective sites, and thus reducing the therapeutic dose, minimizing side effects with an improvement of their therapeutic outcome.

Objectives: This review article highlights the problem of an example of a drug that is used to control Hypertension (HTN). HTN: that is one of eight mortalities worldwide. Approximately one-third of the world's adult population suffers from hypertension (31.1 %, or 1.39 billion people). Hypertension prevalence varies. The World health organization (WHO) Region of Americans has the lowest prevalence of hypertension (18%) and the WHO African Region has the highest prevalence of hypertension (27%) overall. In Egypt, according to WHO, Egypt estimated the number of adult people suffering from hypertension in 2017 was (29.2%) and in 2020, the total percentage of death from hypertension (was 3.93%) of total death. Hypertension is described as a disturbance in the circulatory system accompanied by a sustained increase in systolic and diastolic blood pressure to a level that is likely to have negative effects. The most popular hypertension types in people are first and second hypertension which need to adjust the lifestyle and take medications when these types are not controlled. Several types of medications can be used to control HTN such as Diuretics, Angiotensin-converting enzymes inhibitors (ACEIs), Angiotensin receptor blockers (ARBs) calcium channel blockers (CCBs), and beta-blockers (BBs). All of them can be used individually or in combination with each other to control blood pressure. Beta-blockers (BBs) are one of these drugs that are used for HTN, classified as (first, second, and thirdgeneration). carvedilol (CAR) is one of the most popular drugs used in the third generation. It has additional advantages rather than first and second-generation that α1 -adrenergic receptors antagonist. CAR belongs to BBs but has some drawbacks such as low solubility, low bioavailability, and hepatic metabolism that makes it need to be taken several times a day. Methods: This review contains several articles on CAR nanocarriers application between 2014 to 2022, reviewed by many accepted scientific journals. Results: by application of several approaches of a nanocarrier delivery systems that were used to overcome CAR drawbacks, nano drug delivery can encapsulate CAR lipophilic drug in their core, deliver it to the site of action, sustain CAR release, and enhance the solubility and the bioavailability of this lipophilic drug. Conclusion:This review summarized all recent works that attempt to improve the solubility and the bioavailability of CAR. after the application of several nanocarriers approaches to overcome the drawbacks of CAR, each of these approaches can increase the solubility and the bioavailability of CAR but all of these nanocarriers need many challenges to be applied to be applicable in the market.