Purpose: Cardiopulmonary resuscitation is a lifesaving procedure, performed to preserve patients' life until further management is going to follow. Having basic knowledge of CPR will be a crucial task of medical care providers. This study was done to evaluate knowledge, attitude, and practice and associated factors among clinical year medical students. Participants and Methods:Institutional based cross-sectional study was conducted to assess knowledge, attitude, practice and factors associated with cardiopulmonary resuscitation among clinical year medical students in Jimma University. A simple random sampling was used to assess the students. Structured questionnaire of a question about knowledge, attitude and practice of Cardiopulmonary resuscitation was used to collect the data. The collected data was filled on cleared for completeness, analyzed using SPSS windows version 16 and Chi-square and P-value was calculated. All P-values from 0.05 and below were considered significant. Results:The total response rate for this study is 98%. About 93.3% of the respondents had good knowledge about CPR of which, fifth year (36.2%), fourth year (34.1%) and interns (23%) respectively. Among studied participants (80.7%) students were not practiced CPR. Conclusion:Clinical year medical students had a better knowledge, attitude and practice score towards CPR. Overall, however, the majority of students' knowledge, attitude and practices toward to CPR in Jimma University were not sufficient, favorable and safe enough.