We propose a fast and powerful analysis algorithm, titled Modelbased Analysis of Tiling-arrays (MAT), to reliably detect regions enriched by transcription factor chromatin immunoprecipitation (ChIP) on Affymetrix tiling arrays (ChIP-chip). MAT models the baseline probe behavior by considering probe sequence and copy number on each array. It standardizes the probe value through the probe model, eliminating the need for sample normalization. MAT uses an innovative function to score regions for ChIP enrichment, which allows robust P value and false discovery rate calculations.

Graph Neural Networks (GNNs) have achieved promising performance on a wide range of graph-based tasks. Despite their success, one severe limitation of GNNs is the over-smoothing issue (indistinguishable representations of nodes in different classes). In this work, we present a systematic and quantitative study on the over-smoothing issue of GNNs. First, we introduce two quantitative metrics, MAD and MADGap, to measure the smoothness and over-smoothness of the graph nodes representations, respectively. Then, we verify that smoothing is the nature of GNNs and the critical factor leading to over-smoothness is the low information-to-noise ratio of the message received by the nodes, which is partially determined by the graph topology. Finally, we propose two methods to alleviate the over-smoothing issue from the topological view: (1) MADReg which adds a MADGap-based regularizer to the training objective; (2) AdaEdge which optimizes the graph topology based on the model predictions. Extensive experiments on 7 widely-used graph datasets with 10 typical GNN models show that the two proposed methods are effective for relieving the over-smoothing issue, thus improving the performance of various GNN models.

Collective behaviors of biological swarms have attracted significant interest in recent years, but much attention and efforts have been focused on constant speed models in which all agents are assumed to move with the same constant speed. One limitation of the constant speed assumption without attraction function is that global convergence is quite difficult or even practically impossible to achieve if the speed is relatively fast. In this paper, we propose an adaptive velocity model in which each agent not only adjusts its moving direction but also adjusts its speed according to the degree of direction consensus among its local neighbors. One important feature of the adaptive velocity model is that the speeds of all agents are adaptively tuned to the same maximum constant speed after a short transient process. The adaptive velocity strategy can greatly enhance the global convergence probability, and thus provides a powerful mechanism for coordinated motion in biological and technological multiagent systems.