Topically applied (eyedrop) H2(17)O (10% enrichment) was used in magnetic resonance studies to quantify intraocular water dispersion in vivo. The rate of H2(17)O removed from the aqueous chamber is in the order of 0.1 ml/min/ml of tissue. Similar results are obtained with either proton imaging or 17O spectroscopy. Parallel experiments of direct injection of H2(17)O into the aqueous chamber supported the topical data. Proton MR imaging of H2(17)O dissipation from the aqueous chamber with clinical imagers, coupled with eyedrop application, suggests clinical possibilities.

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A new approach for analysis of RF coils in magnetic resonance (MR) experiments is reported. Instead of assuming current distribution in conventional quasi-static algorithm, this approach transforms the coil geometry into an equivalent circuit for complex current calculation. Self and mutual inductance are taken into consideration. Frequency responses of RF coils and transverse magnetic field (B1) maps can be simulated. This approach is especially efficient for phased array coil design for its small matrix size when implemented on computers. Experiments on both single surface coil and phased array coils are consistent with simulation results. Index Terms-Magnetic resonance, method of moment, phased array coil, RF coil.