This version is available at https://strathprints.strath.ac.uk/59326/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the Strathprints administrator: strathprints@strath.ac.ukThe Strathprints institutional repository (https://strathprints.strath.ac.uk) is a digital archive of University of Strathclyde research outputs. It has been developed to disseminate open access research outputs, expose data about those outputs, and enable the management and persistent access to Strathclyde's intellectual output. COMMUNICATION Concomitant Solid Separation through Electric Field Enhanced CrystallizationWei W. Li, [b] Norbert Radacsi, [b] Herman J.M. Kramer, [b] Antoine E. D. M. van der Heijden [b] and Joop H. ter Horst* [a] Abstract: When applied to a pure component suspension in an apolar solvent, a strong inhomogeneous electric field induces particle movement and the particles are collected at the surface of one of the two electrodes. This new phenomenon was used to separately isolate two organic crystalline compounds, phenazine and caffeine, from their suspension of 1,4-dioxane. First, the crystals of both compounds were collected at different electrodes under the influence of the electric field. Subsequent cooling crystallization allowed the immobilization and growth of the particles on the electrodes, which were separately collected after the experiment with purities higher than 91%. This method can be further developed into a technique for crystal separation and recovery in complex multicomponent suspensions of industrial processes.Crystallization is an effective and efficient separation technology that can, in a single process step, recover the desired compounds from solutions as high purity (>99%) crystalline solids [1,2,3,4] . However, such highly purified product is hard to obtain from a multi-component solution by direct crystallization, such as the product stream from a type-I Multicomponent Reaction (MCR), [5,6] or a racemic mixture of chiral pharmaceutical compounds, [7] since a mixed suspension is a likely result. Further purification of the solid phase usually requires additional steps (see Figure 1 (a) for instance), which will inevitably lead to the loss of valuable products. Alternatively, a single crystallization step coupled with simultaneous particle separation could diminish the product loss wh...

When applied to a pure component suspension in an apolar solvent, a strong inhomogeneous electric field induces particle movement, and the particles are collected at the surface of one of the two electrodes. This new phenomenon was used to separately isolate two organic crystalline compounds, phenazine and caffeine, from their suspension in 1,4‐dioxane. First, crystals of both compounds were collected at different electrodes under the influence of an electric field. Subsequent cooling crystallization enabled the immobilization and growth of the particles on the electrodes, which were separately collected after the experiment with purities greater than 91 %. This method can be further developed into a technique for crystal separation and recovery in complex multicomponent suspensions of industrial processes.