No abstract

In this paper, we consider an energy-constrained unmanned aerial vehicle (UAV)-enabled mobile relay assisted secure communication system in the presence of a legitimate source-destination pair and multiple eavesdroppers with imperfect locations. The energy-constrained UAV employs the power splitting (PS) scheme to simultaneously receive information and harvest energy from the source, and then exploits the time switching (TS) protocol to perform information relaying. Furthermore, we consider a full-duplex destination node which can simultaneously receive confidential signals from the UAV and cooperatively transmit artificial noise (AN) signals to confuse malicious eavesdroppers. To further enhance the reliability and security of this system, we formulate a worst case secrecy rate maximization problem, which jointly optimizes the position of the UAV, the AN transmit power, as well as the PS and TS ratios. The formulated problem is non-convex and generally intractable. In order to circumvent the non-convexity, we decouple the original optimization problem into three subproblems; this facilitates the design of a suboptimal iterative algorithm. In each iteration, we propose a multi-dimensional search and numerical method to handle the subproblem. Numerical simulation results are pro

Molecular recognition ligands are of great significance in many fields, but our ability to develop new recognition molecules remains to be expanded. Here, we developed a Sequential Multidimensional Analysis algoRiThm for aptamer discovery (SMART-Aptamer) from high-throughput sequencing (HTS) data of SELEX libraries based on multilevel structure analysis and unsupervised machine learning to discover nucleic acid recognition ligands with high accuracy and efficiency. We validated SMART-Aptamer with three sets of HTS data from screening pools against hESCs, EpCAM, and CSV. High affinity aptamers for all three targets were successfully obtained, and the results revealed that SMART-Aptamer is able to pick out high affinity aptamers with low false positive and negative rates. With the advantages of accuracy, efficiency, and robustness, SMART-Aptamer represents a paradigm-shift strategy for the discovery of binding ligands for a variety of biomedical applications.