sion of the manuscript. We also thank Marc E. Study approval. All mouse experiments were conducted in accordance with procedures approved by the IACUC of the University of Rochester. In the case of human samples, adult participants from a cohort of control subjects or subjects with EoE at the Center for Esophageal Diseases and Swallowing of the University of North Carolina at Chapel Hill had esophageal biopsies prospectively collected and stored. These samples were provided and analyzed under IRB approval. Adult participants from a cohort of control subjects or subjects with EoE being treated at the Division of Gastroenterology of the University of Pennsylvania were also assessed and were provided under IRB approval. All participants in this study or their parents or legal guardians provided written informed consent.