The common denominator of a unique disseminated multi-focal miliary myocardial hyaline necrosis and fibrosis in Keshan disease (KSD) and cystic fibrosis (CF) and a commonality of the affected age groups of fetuses and preschool children led to the review of existing KSD autopsy material to search for pancreatic and hepatic lesions considered pathognomonic for CF. Pancreatic lesions considered pathognomonic for CF were found in 595, or 35% of 1700 documented cases of KSD. The pancreatic lesions were limited to tissues of fetuses and preschool children. Adults dying of KSD had diagnostic lesions limited to the cardiovascular system, liver, and skeletal muscle. Varying degrees of focal biliary cirrhosis were identified in 850, or 50% of the KSD autopsies, and 85, or 5% developed severe lobular cirrhosis. The common denominator in CF and KSD appears to be a primary or induced secondary selenium deficiency in age-susceptible humans, prenatally at or around 22 wk of fetal life, during early postnatal life, or during the rapid-growth preschool years. The basic difference between the natural history of CF and KSD is that the selenium deficiency is totally environmental in KSD and appears to be the result of a maternal malabsorptive syndrome or an abnormality of selenium transfer in CF.

Os cistos sanguíneos no coração são frequentemente reconhecidos como benignos. Geralmente não causam sintomas clínicos e são frequentemente encontrados em bebês menores de dois meses. 1 Na maioria dos casos, os cistos sanguíneos estão nas válvulas cardíacas ou suas estruturas de suporte. 2 Os cistos cardíacos em adultos são extremamente raros, especialmente nas câmaras do coração. Aqui, relatamos um caso de doença cardíaca valvular complicada com um cisto sanguíneo no átrio direito. As ecocardiografias transtorácica, de contraste e esofágica foram utilizadas para examinar o paciente.

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