This study is concerned with the development of an agent for single photon emission computer tomography (SPECT) for imaging inflammation and tumor progression. [(123)I]Iodooctyl fenbufen amide ([(123)I]IOFA) was prepared from the precursor N-octyl-4-oxo-4-(4'-(trimethylstannyl)biphenyl-4-yl)butanamide with a radiochemical yield of 15%, specific activity of 37 GBq/μmol, and radiochemical purity of 95%. Analysis of the binding of [(123)I]IOFA to COX-1 and COX-2 enzymes by using HPLC and a gel filtration column showed a selectivity ratio of 1:1.3. An assay for the competitive inhibition of substrate transfer showed that IOFA exhibited a comparable IC(50) value compared to fenbufen. In the normal rat liver, a lower level and homogeneous pattern of [(123)I]IOFA radioactivity was observed by SPECT. In contrast, in the rat liver with thioacetamide-induced cholangiocarcinoma, a higher uptake and heterogeneous pattern of [(123)I]IOFA radioactivity was seen as hot spots in tumor lesions by SPECT imaging. Importantly, elevated COX-1 and COX-2 expressions from immunostaining were found in the bile ducts of tumor rats but not of normal rats. Therefore, [(123)I]IOFA was found to exhibit the potential for imaging tumors that over-express COX.

This work experimentally demonstrates the efficacy of the 2 × 2 multiple-input multiple-output (MIMO) technique for capacity improvement of a 60-GHz radio-over-fiber (RoF) system employing single-carrier modulation format. We employ frequency domain equalization (FDE) to estimate the channel response, including frequency response of the 60 GHz RoF system and the MIMO wireless channel. Using FDE and MIMO techniques, we experimentally demonstrate the doubling the of wireless data capacity of a 60 GHz RoF system to 27.15 Gb/s using 16-QAM modulation format, with transmission over 25 km of standard single-mode fiber and 3 m wireless distance.