Previous MRI studies confirmed abnormalities in the limbic-cortical-striatal-pallidal-thalamic (LCSPT) network or limbic-cortico-striatal-thalamic-cortical (LCSTC) circuits in patients with major depressive disorder (MDD), but few studies have investigated the subcortical structural abnormalities. Therefore, we sought to determine whether focal subcortical grey matter (GM) changes might be present in MDD at an early stage. We recruited 30 first episode, untreated patients with major depressive disorder (MDD) and 26 healthy control subjects. Voxel-based morphometry was used to evaluate cortical grey matter changes, and automated volumetric and shape analyses were used to assess volume and shape changes of the subcortical GM structures, respectively. In addition, probabilistic tractography methods were used to demonstrate the relationship between the subcortical and the cortical GM. Compared to healthy controls, MDD patients had significant volume reductions in the bilateral putamen and left thalamus (FWE-corrected, p < 0.05). Meanwhile, the vertex-based shape analysis showed regionally contracted areas on the dorsolateral and ventromedial aspects of the bilateral putamen, and on the dorsal and ventral aspects of left thalamus in MDD patients (FWE-corrected, p < 0.05). Additionally, a negative correlation was found between local atrophy in the dorsal aspects of the left thalamus and clinical variables representing severity. Furthermore, probabilistic tractography demonstrated that the area of shape deformation of the bilateral putamen and left thalamus have connections with the frontal and temporal lobes, which were found to be related to major depression. Our results suggested that structural abnormalities in the putamen and thalamus might be present in the early stages of MDD, which support the role of subcortical structure in the pathophysiology of MDD. Meanwhile, the present study showed that these subcortical structural abnormalities might be the potential trait markers of MDD.

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In this paper, we propose a novel Human-like Semantic Cognition Network (HSCN) for aspect-level sentiment classification, motivated by the principles of human beings’ reading cognitive process (pre-reading, active reading, post-reading). We first design a word-level interactive perception module to capture the correlation between context words and the given target words, which can be regarded as pre-reading. Second, to mimic the process of active reading, we propose a targetaware semantic distillation module to produce the targetspecific context representation for aspect-level sentiment prediction. Third, we further devise a semantic deviation metric module to measure the semantic deviation between the targetspecific context representation and the given target, which evaluates the degree we understand the target-specific context semantics. The measured semantic deviation is then used to fine-tune the above active reading process in a feedback regulation way. To verify the effectiveness of our approach, we conduct extensive experiments on three widely used datasets. The experiments demonstrate that HSCN achieves impressive results compared to other strong competitors.

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