This study was to explore the curative effect of early enteral nutrition (EN) of three-cavity nasal jejunal tube (NJT) based on nano superparamagnetic iron oxide (SPIO) in treating severe acute pancreatitis (SAP). After the Fe3+ and Fe2+ were mixed, the ions were
co-precipitated to generate Fe3O4 nanoparticles, which were used as seeds for the sodium citrate-auric acid reduction reaction to form the gold-coated SPIO nanoparticles. 90 patients with severe AP were selected and randomly rolled into blank group (group B), control
group (group C), and experimental group (group E), with 30 cases in each group. The three groups of patients were treated with complete parenteral nutrition support, EN through three-cavity NJT, an EN through three-cavity NJT under the guidance of SPIO nanoparticles, respectively. The resulted
showed that the Acute Physiology and Chronic Health Evaluation (APACHE II) score (11.6±1.62) of the group E was much lower in contrast to the group B (16.34±1.45) and the group C (15.8±1.33) (P < 0.05). The computed tomography severity index (CTSI) in group E
(5.03±0.65) was greatly lower than that in the group B (6.01±0.39) and the group C (5.89±0.44) (P < 0.05). Compared to the group B (14.5±1.25), the time required for the blood amylase to return to normal in the group C and the group E (11.8±1.39,
7.3±1.4) was shorter visibly (P < 0.05). The Visual Analogue Scale (VAS) scores during and after the placement of NJT were the lowest (P < 0.05). In short, the nutritional support through three-cavity NJT for patients with SAP was safe and effective, and had a positive
effect on preventing infection and improving body function; in addition, the application of SPIO nanoparticles could help relieve patients’ pain and reduce adverse events.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.