n-3 PUFA supplements may significantly improve cognitive development in infants but do not improve cognitive performance in children, adults, or the elderly. n-3 PUFA intake, especially that of DHA supplements, may benefit cognitive development during infancy.

Acrylamide is classified as a probable carcinogen to humans and generated from Maillard reaction. Currently, the short-term exposure to acrylamide was evaluated via external diet sources in vitro or two main mercapturic acid metabolites: N-acetyl-S-(2-carbamoylethyl)-L-cysteine (AAMA) and N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine (GAMA) in vivo. In the present work, we comprehensively profiled four mercapturic acid metabolites and evaluated their internal exposure in rats and Chinese adolescents. The cumulative excretion of mercapturic acid metabolites contributes 38.4-73.0 and 43.8-63.6 % of total in vivo metabolites of acrylamide in male and female rats, respectively, when 1, 10, and 50 mg/kg bw of acrylamide were orally administered. Toxicokinetic study revealed that the conversion of acrylamide into glycidamide and glutathione coupling process is highly related to the gender and oral gavage dose via evaluating kinetic parameters, accumulative excretion percentages, and molar ratios of oxidative to reductive metabolism. In human study, a total of 101 Chinese adolescents (41 men and 60 women) were enrolled and served with a meal of potato chips, corresponding to a single-dose (12.6 μg/kg bw) exposure to acrylamide. Toxicokinetic work showed that AAMA is an early and predominant metabolite appearing as a biomarker in urine. N-acetyl-S-(2-carbamoylethyl)-L-cysteine-sulfoxide (AAMA-sul), an oxidative product from AAMA, exhibits a higher peak concentration than GAMA and N-acetyl-S-(1-carbamoyl-2-hydroxyethyl)-L-cysteine (iso-GAMA) during the whole 48-h toxicokinetic period. The internal exposure via four mercapturic acid metabolites is associated with the gender and body mass index characteristics. Thus, current study aims at mercapturic acid metabolites as urinary biomarkers and provides comprehensive insights into the short-term internal exposure to acrylamide.

The detection of elongated objects, such as ships, from satellite images has very important application prospects in marine transportation, shipping management, and many other scenarios. At present, the research of general object detection using neural networks has made significant progress. However, in the context of ship detection from remote sensing images, due to the elongated shape of ship structure and the wide variety of ship size, the detection accuracy is often unsatisfactory. In particular, the detection accuracy of small-scale ships is much lower than that of the large-scale ones. To this end, in this paper, we propose a hierarchical scale sensitive CenterNet (HSSCenterNet) for ship detection from remote sensing images. HSSCenterNet adopts a multi-task learning strategy. First, it presents a dual-direction vector to represent the posture or direction of the tilted bounding box, and employs a two-layer network to predict the dual direction vector, which improves the detection block of CenterNet, and cultivates the ability of detecting targets with tilted posture. Second, it divides the full-scale detection task into three parallel sub-tasks for large-scale, medium-scale, and small-scale ship detection, respectively, and obtains the final results with non-maximum suppression. Experimental results show that, HSSCenterNet achieves a significant improved performance in detecting small-scale ship targets while maintaining a high performance at medium and large scales.

Polyphenolic antioxidants may effectively reduce acrylamide contents in processing foods. However, few studies focused on their detoxification effects via estimating the profile change of internal exposure biomarkers. Here we showed...

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