We have built a rat's model to investigate whether the hypothermia induced by adenosine 5′-monophosphate (5′-AMP) (AIH) could attenuate acute lung injury induced by LPS in rats. We detected the inflammatory cytokine levels in the plasma and bronchoalveolar lavage fluid samples, and we analyzed the pathological changes in the lungs. We have found that AIH can effectively inhibit acute inflammatory reactions and protect the lung from acute injury induced by LPS in rats.

Hypothermia induced by 5'-AMP could inhibit the acute inflammatory reaction and NF-κB activation associated with acute pancreatitis.

To investigate whether the hypothermia induced by Adenosine 5'-Monophosphate (5'-AMP) could attenuate early stage injury in a rat acute gouty arthritis model. Ankle joint injection with monosodium urate monohydrate crystals (MSU crystals) in hypothermia rat model which was induced by 5'-AMP and then observe whether hypothermia induced by 5'-AMP could be effectively inhibit the inflammation on acute gouty arthritis in rats. AMP-induced hypothermia has protective effects on our acute gouty arthritis, which was demonstrated by the following criteria: (1) a significant reduction in the ankle swelling (p < 0.001); (2) a significant decrease in the occurrence of leukocyte infiltration and mild hemorrhage; (3) a significant reduction in the presence of serum Interleukin-1β (IL-1β, p < 0.001) and metalloproteinase-9 (MMP-9, p < 0.001); and (4) a significant inhibition in the Nuclear Factor -κappaB (NF-κB) activity (p < 0.001). AMP-induced hypothermia could inhibit acute inflammation reaction and protect the synovial tissue against acute injury in a rat acute gouty arthritis model.

Two chain-like coordination polymers, namely, {[Zn(saes)(4,4'-bipy)(H 2 O)]·H 2 O} n (1) and {[Cd (Hsaes) 2 (4,4'-bipy)(H 2 O) 2 ]·2H 2 O} n (2), where H 2 saes = 2-(2-hydroxybenzylideneamino)ethanesulfonic acid and 4,4'-bipy = 4,4'-bipyridine, have been synthesized and characterized by singlecrystal X-ray diffraction, IR spectroscopy, elemental, thermogravimetric and photoluminescence analysis. X-Ray diffraction analyses indicate that 1 and 2 display octahedral metal centers with N 3 O 3 and N 2 O 4 donor sets, respectively. The Schiff base serves as a common N,O,O'-tridentate ligand in 1, and as a unique O-monodentate ligand in 2. In the crystal, both 1 and 2 form a 3D supramolecular architecture by O-H· · ·O, C-H· · ·O interactions or π· · ·π stacking. The thermal and solid-state photoluminescence properties of both complexes have been investigated.

Key indicators: single-crystal X-ray study; T = 296 K; mean (C-C) = 0.005 Å; R factor = 0.062; wR factor = 0.200; data-to-parameter ratio = 14.0.In the centrosymmetric title compound, C 12 H 10 O 2 S 2 , the alkyl chains adopt a fully extended all-trans conformation with respect to the C(thiophene)-C bond. The non-H atoms of the molecule are nearly planar, with a maximum deviation of 0.063 (2) Å from the mean plane of the constituent atoms. In the crystal, symmetry-related molecules are linked via pairs of C-HÁ Á Á contacts [H-centroid distances of the thiophene units = 2.79 (9) and 2.82 (4) Å ], in turn interdigitating with each other along the bc plane, thus leading to an interwoven two-dimensional network. Related literature