In this paper, we compared the domestic and foreign research situation in the field of genomics from the perspective of bibliometrics, aiming to provide some references for further study. We retrieved genomics related literature through the Web of Science and CNKI from 1985 to 2016, and then analyzed the number of published articles, the networks of collaboration among authors, research institutes and countries, the co-occurrence of keywords and co-citations of the retrieved literature through the software CiteSpace 4.0.R5 SE. The number of published periodical articles develops in fluctuation and shows a rising trend in general. The USA holds the largest share of world publications in genomics, the following is the UK and China in order. A core institution with considerable scale has formed in America and good cooperative relationships have been established between universities in the institution. Chinese Academy of Sciences is the main research institution in China. The cooperation between the international institutions is more often and closer than that at home. The researchers with the most articles published in Chinese and foreign journals are Liu J.Q. and Zhang Y respectively. The main co-occurrence and burst keywords are Pharmacogenomics, Functional genomics, Comparative genomics, Proteomics, etc. The articles with the highest centrality, highest citation frequency and highest burst strength are (Yang, 2007), (Lander, 2001) and (Altschul, 1997), respectively. Interagency cooperation should be enhanced so as to push forward the development of genomics research in China.