This article uses empirical evidence from the UK to consider how demand for external finance changed as the economy entered recession and whether external finance became more difficult for entrepreneurs to access as the recession progressed. It finds that larger firms and those experiencing declines in sales were more likely to maintain or increase their demand for external finance. The opposite was true for women-led businesses. Generally, finance was more readily available to larger and older firms throughout the recession. At its peak 119,000 (10% of the total stock) smaller firms were denied credit in a three-month period.

We use UK data to consider how smaller firms coped during the financial crisis. This is important as smaller firms are major contributors to job creation, but are vulnerable to falling demand. We find that 4 in 10 smaller firms experienced a fall in employment during the recession, and 5 in 10 a fall in sales. Within 12 months of the recession, three-quarters of entrepreneurs had a desire to grow. This suggests that whilst the immediate effects of recession are severe, entrepreneurs recover quite quickly. Importantly, recessionary growth is hugely concentrated amongst entrepreneurs with the highest human capital

Pomegranate shows neuroprotective effects against Alzheimer's disease (AD) in several reported animal studies. However, whether its constituent ellagitannins and/or their physiologically relevant gut microbiota-derived metabolites, namely, urolithins (6H-dibenzo[b,d]pyran-6-one derivatives), are the responsible bioactive constituents is unknown. Therefore, from a pomegranate extract (PE), previously reported by our group to have anti-AD effects in vivo, 21 constituents, which were primarily ellagitannins, were isolated and identified (by HPLC, NMR, and HRESIMS). In silico computational studies, used to predict blood-brain barrier permeability, revealed that none of the PE constituents, but the urolithins, fulfilled criteria required for penetration. Urolithins prevented β-amyloid fibrillation in vitro and methyl-urolithin B (3-methoxy-6H-dibenzo[b,d]pyran-6-one), but not PE or its predominant ellagitannins, had a protective effect in Caenorhabditis elegans post induction of amyloid β(1-42) induced neurotoxicity and paralysis. Therefore, urolithins are the possible brain absorbable compounds which contribute to pomegranate's anti-AD effects warranting further in vivo studies on these compounds.

The availability of credit to entrepreneurs with good investment opportunities is an important facilitator of economic growth. Under normal eco- nomic conditions, most entrepreneurs who requested loans receive them. In a global financial crisis, popular opinion is that banks are severely restricting lending to smaller businesses. This assumes that low levels of investment are caused by supply-side restrictions in the credit market. Little is said about potential changes in the demand for credit and how it is influenced by entrepreneurs’ perceptions about supply-side restric- tions. One particularly interesting, and under-re- searched, group of small businesses is that who have potentially good investment opportunities, but are discouraged from applying for external funding as they fear rejection. In this study, we question whether these entrepreneurs were correct in their assumptions. We find that levels of discouragement are quite low in general at 2.7 % of the total smaller business popu- lation. Further analysis implies that 55.6 % of dis- couraged borrowers would have got loans had they applied