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BACKGROUND Background: Stroke is one of the main causes of chronic disability and death, and infection is the most common complication of stroke and the main influencing factor of 30d mortality. Studies have shown that statins can reduce the incidence and mortality of cardiovascular and cerebrovascular events, as well as the expression of inflammatory factors. However, the effect of statins on the prognosis of patients with acute ischemic stroke complicated with infection has not been determined. OBJECTIVE Objective: To reduce the infection rate in patients with acute ischemic stroke, effect of statins on patients with acute ischemic stroke infection based on intelligent data acquisition of computed tomography image information was investigated. METHODS Methods: In this study, 122 infected patients with acute ischemic stroke in our hospital from June 2016 to December 2018 were included as subjects, and they were divided into test group (statin treatment, n=69) and control group (non-statin treatment, n=53). On admissionon, the differences in baseline data, stroke classification, neurological impairment, and the number of affected cerebral lobes between the two groups were compared; the probability of pulmonary, urinary system, and co-infection in patients with different stroke types was compared; the modified Rankin score and pap scale were used to evaluate the prognosis of patients; filter back projection (FBP) and iDose4 algorithms were used to reconstruct CT images of stroke patients, and the differences in noise and Signal to Noise Ratio (SNR) of reconstructed images by different algorithms were compared; CT images were used to qualitatively and quantitatively analyze the imaging characteristics of stroke patients and the affected cerebral lobes. RESULTS Results: The proportion of TACI in the control group was significantly higher than that in the test group (P<0.01); the incidence of pulmonary infection in patients with total anterior circulation infarct (TACI) typing in the control group was significantly higher than that in the test group (P<0.01); the Rankin and Barthel index scores of the test group at 0 months (3.30±0.34 vs 4.19±0.42; 45.71±8.26 vs 29.65±5.58), 1 months (3.17±0.36 vs 4.39±0.47; 47.79±7.79 vs 31.97±6.02), and 2 months (3.16±0.32 vs 4.14±0.40; 59.33±9.87 vs 35.80±6.21) were significantly higher than those of the control group (P<0.05); the noise in the image reconstructed by iDose4 method was significantly lower than that by FBP method (P<0.01); there were statistically significant differences between the control group and the test group in the proportion of involvement in the right parietal lobe, left insula, left internal capsule, subcortex, and right brain stem (P<0.05), CONCLUSIONS Conclusions: iDose algorithm can more effectively reconstruct CT images of stroke patients, and statins can significantly improve the left internal capsule and subcutaneous involvement of stroke patients, so as to effectively improve the prognosis of patients with acute stroke. CLINICALTRIAL Trial Registration: CRD42017079863