Background: Headache is considered as one of the most common disorders of the central nervous system , and there are many types of it. One of them is migraine headache. Worldwide it is a common disabling primary headache syndrome. Medical students most of the time are exposed to its various triggers. This might have huge impact on their lives and their academic performance. This topic has been studied in many countries to highlight the prevalence of migraine headache and to study its impact on the students' life and academic performance. Unfortunately, no similar study was conducted neither in Jazan Area nor in Saudi Arabia as a whole Objectives: The main goal of this study was to know the prevalence of migraine headache among medical students at Jazan University and to assess its effect on their daily activities. Methods: A cross-sectional survey was conducted during 2016-2017 academic year in Jazan university. 260 students were examined. The data were collected by using self-administered questionnaire which included demographic data and specific questions on headache based on international Headache Society criteria for diagnosis of migraine and other headache types. The collected data were analyzed by using SPSS program. Results: The results showed that the prevalence of migraine among medical students was 5.0%. There was no significant difference between the gender according to p-value , but regarding the years of university studying there was significant difference in which the prevalence increased in parallel with advancing academic years at the university. Conclusion: the prevalence of migraine among medical students was found to be less than what seen in similar studies in different countries , without significant difference between the gender. All the students reported that the headache was interfering with their daily activities. Fatigue, too little sleep, and bright light were the most common triggering factors were identified in our study.