This paper mainly takes Zhacun goldmine as the research object and carries out research on the metallogenic system and genesis of the deposit in the area. The research methods are as follows: according to the geological characteristics of the metallogenic mining area in the Zhacun goldmine, combined with the comparative analysis of the metallogenic age, alteration characteristics and lithology between the Zhacun goldmine and the Lianhuashan alkali rich rock mass, and the analysis of the isotopic data in the Zhacun goldmine, this paper demonstrates that the magmatic activity of the Lianhuashan quartz monzonite porphyry plays an important role in the mineralization of this area, which is both an important ore source and fluid source. It is also the main heat source driving the circulation of ore-forming fluid. On this basis, through the analysis of the metallogenic elements in the area, the metallogenic system model of Zhacun goldmine is constructed. It is considered that under the action of long-term horizontal compressive stress, the atmospheric precipitation infiltrated into the formation continued to penetrate along the fractures and fissures to deep crust and finally mixed with the magmatic water sealed in the thick formation. During this period, a series of shallow and ultrashallow porphyry mass intruded, providing heat source and part of the ore-forming materials and resulting in incomplete homogenization under high temperature and high pressure, which formed highly mineralized mixed water. Under the combined action of long-term compressive stress and various deep thermal dynamics, these mineral fluids migrated along the buried deep faults near the core of the duplex anticline to the upper part of the crust. When the metal elements in these ore fluids migrated over long distances to the nappe fault zone of the gold-bearing fracture zone, the gold began to precipitate, and the native gold and the coarse-grained pyrite and quartz formed at the same time or earlier started to fill the fracture zone along the fissures and accumulate into minerals. Then, through the analysis of metallogenic conditions, gold mineralization process, and genetic mechanism of the deposit, it is proposed that the genetic type of the ore deposit in this area is magmatic mesothermal-epithermal gold deposit. The establishment of metallogenic system model in Zhacun goldmine will provide theoretical and practical guidance for deep and peripheral prospecting prediction in the area, carry out targeted and reasonable prediction, and improve prospecting effectiveness.