Review question / Objective: The objective of the present review is to find out whether vitamin D could be effective on patients with sepsis.Condition being studied: Sepsis.

Review question / Objective: Can periodontitis increase the risk of heart failure? Condition being studied: Previous studies reported that periodontal disease is associated with higher risk of HF. However, their conclusions conflicted a little bit with each other. In this case, a systematic review may help drawing a more comprehensive conclusion. Therefore, the purpose of the present analysis is to tell if periodontitis is associated with HF as well as the subtypes of HF.

Review question / Objective: 1 Whether metformin can reduce the incidence of asthma in patients with T2D. 2 Whether T2D patients with concurrent asthma can safely use metformin to reduce adverse outcomes. Condition being studied: Recent epidemiological studies suggest that metformin, the first-line medication used for T2D patients, may reduce the risk of asthma exacerbations. Therefore, this article aims to explore two research questions: first, whether metformin can reduce the incidence of asthma in patients with T2D, and second, whether T2D patients with concurrent asthma can safely use metformin to reduce adverse outcomes. This study may shed light on the efficacy of metformin as an adjunct therapy for asthma care in patients with co-morbid T2D.