According to the requirements of fatigue test of aircraft cabin, large engine and mining machinery for heavy-duty six dimensional generalized force sensors, a new method of using piezoelectric quartz as force-sensitive element on the basis of the theory of heavy force division and equivalent capacity compression is proposed in this study. Furthermore, in order to minimize the force-coupling for the six-dimension force sensor, the optimization objective function is devised and the calculation method for decoupling is also proposed, on the basis of which, the generalized force sensor with high sensitivity, high stiffness, high linearity but light in its weight is designed. At last, the static calibration experiment is carried out the result shows that the sensor has a good ability of heavy force division and capacity for equivalent compression it can be well used in large tonnage six component force loading device and fatigue test system.