A facile synthesis of cyclic aminodiborane (NH2B2H5, ADB) from ammonia borane (NH3·BH3, AB) and THF·BH3 has made it possible to determine its important characteristics. Ammonia diborane (NH3BH2(μ-H)BH3, AaDB) and aminoborane (NH2BH2, AoB) were identified as key intermediates in the formation of ADB. Elimination of molecular hydrogen occurred from an ion pair, [H2B(NH3) (THF)](+)[BH4](-). Protic-hydridic hydrogen scrambling was proved on the basis of analysis of the molecular hydrogen products, ADB and other reagents through (2)H NMR and MS, and it was proposed that the scrambling occurred as the ion pair reversibly formed a BH5-like intermediate, [(THF)BH2NH2](η(2)-H2)BH3. Loss of molecular hydrogen from the ion pair led to the formation of AoB, most of which was trapped by BH3 to form ADB with a small amount oligomerizing to (NH2BH2)n. Theoretical calculations showed the thermodynamic feasibility of the proposed intermediates and the activation processes. The structure of the ADB·THF complex was found from X-ray single crystal analysis to be a three-dimensional array of zigzag chains of ADB and THF, maintained by hydrogen and dihydrogen bonding. Room temperature exchange of terminal and bridge hydrogens in ADB was observed in THF solution, while such exchange was not observed in diethyl ether or toluene. Both experimental and theoretical results confirm that the B-H-B bridge in ADB is stronger than that in diborane (B2H6, DB). The B-H-B bridge is opened when ADB and NaH react to form sodium aminodiboronate, Na[NH2(BH3)2]. The structure of the sodium salt as its 18-crown-6 ether adduct was determined by X-ray single crystal analysis.

We report the hydroboration of CO with catecholborane catalyzed by a series of bis(phosphinite) pincer ligated nickel thiolate complexes. Turnover frequencies (TOFs) up to 2400 h were achieved at room temperature under an atmospheric pressure of CO. This represents the highest TOF value known to date for the reduction of CO to the methoxide level under mild conditions.

A series of nickel pincer complexes of the type [4-Z-2,6-(R 2 PO) 2 C 6 H 2 ]NiX (R = t Bu, i Pr, Ph; Z = H, CO 2 Me; X = NCS, N 3 ) have been synthesized from the reactions of the corresponding nickel chloride complexes [4-Z-2,6-(R 2 PO) 2 C 6 H 2 ]NiCl and potassium thiocyanate or sodium azide. X-ray structure determinations of these complexes have shown that the thiocyanate ion binds to the nickel center through the nitrogen. A comparable Ni-N bond length (approx. 1.87 Å for the isothiocyanate complexes and 1.91 Å for the azide complexes) and an almost identical Ni-C ipso bond length (approx. 1.89 Å) have been observed for these complexes. Metathesis reactivity of [4-Z-2,6-(R 2 PO) 2 C 6 H 2 ]NiCl and ligand exchange reactions between the nickel isothiocyanate and nickel azide complexes have been investigated. The metathesis reactions with thiocyanate/azide complexes are faster with a less electron rich and more sterically accessible nickel center. The thermodynamic stability of these nickel complexes has been rationalized using the hard-soft acid-base theory (HSAB theory); a harder ligand prefers a less electron rich nickel center. These © 2015. This manuscript version is made available under the Elsevier user license http://www.elsevier.com/open-access/userlicense/1.0/ 2 experimental results have been supported by quantum chemical analysis of the coordinating nitrogen atoms in SCNand N 3 -.

Through the microarray analysis, long noncoding RNA TPT1-AS1 (TPT1-AS1) was identified in the development of glioma. However, the specific effect of TPT1-AS1 on glioma autophagy in the recent years has not fully been investigated. Therefore, the purpose of our present study is to investigate the function of TPT1-AS1 on affecting autophagy of glioma cells through regulation of microRNA-770-5p (miR-770-5p)-mediated How to cite this article: Jia L, Song Y, Mu L, et al. Long noncoding RNA TPT1-AS1 downregulates the microRNA-770-5p expression to inhibit glioma cell autophagy and promote proliferation through STMN1 upregulation.

Background: We aimed to investigate the effects of occupational stress on blood lipids, blood glucose and immune function of doctors. Methods: In 2017, 1291 doctors (565 males, 726 females) in The First Hospital Affiliated with Harbin Medical University (Harbin, China) were enrolled based on the principle of convenience of sampling and cluster sampling. Questionnaires were used to investigate demographic characteristics and occupational stress related factors. Level of glycated hemoglobin was detected by immunoturbidimetric method. Concentration of triglyceride was determined by        glycerol phosphate oxidase end point method. Total cholesterol concentration in serum was determined by total cholesterol oxidase end point method. Concentration of serum immunoglobulin was detected by immunoturbidimetry. Results: Levels of glycated hemoglobin and triglyceride in high tension group were higher than those in the low tension group. Levels of IgG and IgM in high tension group were lower than those in low tension group. The risk of elevated glycated hemoglobin levels in > 50-yr-old age group was higher than that of the =<35-yr-old age group. Those in the high coping strategy group was higher in the low coping strategy group. The risk of elevated total cholesterol levels in drinkers is 1.158 times that of non-drinkers. The risk of IgG concentration reduction in smokers was 0.428 times that of non-smokers. The risk of a decrease in IgA concentration in doctors with good sleep quality is 1.527 times that of those with poor sleep quality. Conclusion: Occupational stress can lead to increased blood lipids and sugar levels as well suppression of immune function in doctors.