The physiological phenomenon of wound contraction in mice cannot completely imitate the process of human skin regeneration, which is primarily attributed to reepithelialisation. As such, excisional wound models in mice are considered to be imperfect comparisons. This study aimed to enhance the correlation of mouse excisional wound models with that of humans, and to offer more practical and accurate ways to record and measure wound areas. We present evidence that simple excisional wounds produce a robust and stable wound model by comparing splint‐free and splint groups. We monitored reepithelialisation and contraction in the C57BL/6J mouse excision wound model at different time points and prove that excisional wounds heal by both contraction and reepithelialisation. Some parameters were measured and a formula was used to calculate the area of wound reepithelialisation and contraction. In our results, reepithelialisation accounted for 46% of the wound closure of full‐thickness excisional wounds. In conclusion, excisional wound models can be used as wound‐healing models and a straightforward formula may be used to determine the process of reepithelialisation over a wound bed created by a simple excisional rodent wound model.

BackgroundThe number of patients with osteoporosis or low bone mass is increasing annually. Weight loss is reportedly associated with bone loss and is a strong predictor of osteoporosis. It was still not clear the relationship between weight loss and bone loss in the elder.MethodsThe study included 520 patients aged ≥65 years (178 men and 342 women). Age, gender, weight, and height were recorded. Femoral neck bone mineral density and T-score were investigated using a dual-energy X-ray absorptiometry scanner. Blood calcium (Ca), phosphorus (P), albumin (ALB), alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels were measured. Patients were classified by gender (male and female), age (65-79 years and ≥80 years), and T-score: normal, osteopenia and osteoporosis.ResultsAge, gender, body mass index (BMI), ALP and TG were independent factors for osteoporosis. For the 65-79 and ≥80 year age groups, female patients presented lower T-scores than males. Ca, P, ALB, ALP, TC, HDL and LDL levels were significantly different between men and women in the 65-79 year age group. In addition, BMI and TG levels were significantly decreased in osteoporotic patients compared with normal bone mass patients. TC levels declined in 65-79 year-old male and female patients with osteoporosis. In the group of women aged ≥80 years, osteoporotic patients showed significantly increased ALP levels. Furthermore, we found positive correlations between BMI and TG levels in the groups of male and female patients. However, we found no significant differences in ALB, Ca, P, HDL and LDL levels in osteoporotic compared to normal bone mass patients.Conclusion Osteoporotic patients showed significantly decreased BMI and TG levels compared with those with normal bone mass. BMI was showed positive correlations with TG levels in male and female patients. These results indicate a correlation between weight loss and bone loss and a correlation between lipid profiles and bone mass.