Abstract. Lung cancer is one of the most common types of tumors and the leading cause of cancer-associated mortality in the world. Additionally, non-small cell lung cancer (NSCLC) accounts for ~80% of all lung cancer cases. Epithelialmesenchymal transition (EMT) is an important cell biological process, which is associated with cancer migration, metastasis, asthma and fibrosis in the lung. In the present study, it was revealed that miR-145-5p was able to suppress EMT by inactivating the c-Jun N-terminal kinase (JNK) signaling pathway in NSCLC cells. Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) was predicted and confirmed to be a novel target of miR-145-5p. Overexpression of MAP3K1 was able to reverse the inhibition of EMT induced by miR-145-5p via the JNK signaling pathway. Overall, the results revealed that miR-145-5p inhibits EMT via the JNK signaling pathway by targeting MAP3K1 in NSCLC cells.

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With the adjustment of the strategic planning of China's automobile industry, the national policy strongly supports the development and large-scale application of hybrid power technology, but there is no guidance document on the testing and evaluation standards of hybrid power units. In this paper, the current situation of testing and evaluation technology of hybrid power units at home and abroad is analyzed in detail, and combined with the working characteristics of hybrid power units, the testing and evaluation methods that are more in line with the working characteristics of hybrid power units are put forward. They are the individual test of hybrid power unit parts, the test method of independent control of engine load and motor load, and the test method of total load control of hybrid power unit.

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