Advanced, late-stage Epstein-Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC) is incurable, and its treatment remains a clinical and therapeutic challenge. Results from a phase II clinical trial in advanced NPC patients employing a combined chemotherapy and EBV-specific T cell (EBVST) immunotherapy regimen showed a response rate of 71.4%. Longitudinal analysis of patient samples showed that an increase in EBV DNA plasma concentrations and the peripheral monocyte-to-lymphocyte ratio negatively correlated with overall survival. These parameters were combined into a multivariate analysis to stratify patients according to risk of death. Immunophenotyping at serial time points showed that low-risk individuals displayed significantly decreased amounts of monocytic myeloid-derived suppressor cells postchemotherapy, which subsequently influenced successful cytotoxic T-lymphocyte (CTL) immunotherapy. Examination of the low-risk group, 2 weeks post-EBVST infusion, showed that individuals with a greater overall survival possessed an increased frequency of CD8 central and effector memory T cells, together with higher levels of plasma interferon (IFN)-g, and cytotoxic lymphocyte-associated transcripts. These results highlight the importance of the rational selection of chemotherapeutic agents and consideration of their impact on both systemic immune responses and downstream cellular immunotherapy outcomes.

The cyclone is an important part of the combustion chamber of the gas turbine and has a direct impact on the combustion performance in the combustion chamber. Therefore, it is of great value to study the structural characteristics of the cyclone. This paper firstly analyses the structural characteristics of cyclone that have the greatest impact on the performance of the combustion chamber through the relevant data and the structural parameters of the actual combustion chamber. Then appropriately simplifies the structure of the combustion chamber, designing a F-class combustion chamber with cyclone. Numerical simulation method is compared with the actual combustion chamber data to verify whether the design of the cyclone meets the requirements, thus preliminary determining the blade installation structure and the number of blades of the combustion chamber cyclone. In the end, using the model combustion chamber as a blueprint, adjust the blade characteristics of the cyclone for different installation angles (40°, 45°, and 50°) and the number of blades (6, 8, and 10). The combustion chamber model is simulated to determine that the flow field of the combustion chamber is the best when the angle is 45°and the number of blades is 8.

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