3-Alkylquinoxalin-2(1H)-ones are synthesized via direct alkylation of quinoxalin-2(1H)-ones at the C3 position under visible light irradiation.

A visible-light-promoted radical acylation/cyclization cascade reaction of N-methacryloylbenzamides with α-keto acids was developed to construct acylated isoquinoline-dione derivatives.

An efficient method for the synthesis of 3trifluoromethylquinoxalin-2(1H)-ones by a direct trifluoromethylation of quinoxalin-2(1H)-one derivatives has been developed under transition-metal-free conditions. The strategy uses cheap and commercially available PhI(OAc) 2 as a promoter, TMSCF 3 as a trifluoromethylation reagent in the presence of catalytic amount of benzoquinone to give the products in good yields.

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A metal- and additive-free strategy for the synthesis of oxindoles has been achieved through a chlorine radical-induced cascade chlorination/carbocyclization of N-aryl acrylamides. Trichloroiso­cyanuric acid (TCCA) is used as both radical initiator and chlorine source. A wide range of substrates can be applied in this process to directly afford chlorinated oxindoles via C–Cl and C–C bond formation.