Structural and chemical alterations in living tissue are reflected in electrical impedance changes. However, due to the complexity of skin structure, the relation between electrical parameters and physiological/pathological conditions is difficult to establish. The impedance dispersion reflects the clinical status of the examined skin tissue and, therefore, it is frequently used in a non-invasive evaluation of exposing skin to various factors. The method has been used to assess the effect of the fish collagen on the skin of patients suffering from the leg ulcer. Therefore, from a number of different approaches to skin electrical impedance dispersion, the one considered to be safe was selected and applied. This paper presents a short review of different technical approaches to in vivo electrical impedance measurements, as well as an analysis of the results and the effect of fish collagen locally administered on human skin.

Aging is an inevitable biological process, during which the activity of cells decreases and their regenerative capacity declines. These processes can be modified through treatment procedures in the field of esthetic medicine and cosmetology. Contemporary esthetic medicine has confirmed that formulations containing stem cells and growth factors have a favorable impact on the appearance of the skin due to improving and regenerating the skin structure, and at the same time enhancing its elasticity and firmness. 1-3 The skin is the outer covering the human body. It is thinner in places less exposed to mechanical damage and thicker in places that are more exposed to potential damage. The skin consists of

Introduction: Venous ulcers are difficult to heal chronic wounds. Most challenging are the non-healing and recurrent ulcers, because of which we are seeking for therapies that stimulate and support their healing. Aim: To assess the efficacy of fish collagen and its impact on the process of healing of venous leg ulcers. Material and methods: This 12-week randomized single-centre study included a total of 97 adults with venous leg ulcer, randomized into two groups: the study group (n = 48) and the control group (n = 49). All patients received specialist medical care including skin and limb care, wound development according to the TIME scheme (tissue debridement, infection and inflammation control, moisture balance, edge) and short-stretch bandage compression (compression class II). In addition, the study group received tropocollagen gel applied to the skin around the wound. Every 2 weeks we evaluated the wound surface and temperature distribution on the shin (average temperature, median, minimum and maximum) -symmetrically on the sick and healthy limb. Results: We observed a greater number of complete ulcer healing in the study group (week 12: 29.2% vs. 22.4%; week 24: 52.1% vs. 36.7%). Faster healing time in the study group was observed in both big and small ulcers. The thermographic analysis showed statistically significant reduction in periwound inflammation among patients from the study group (p < 0.05). Statistically significant reduction in mean as well as maximum values of limb temperature occurred only in the study group (Tx: R = 0.37, p < 0.001; Tmax: R = 0.40, p < 0.001). Conclusions: Thermographic analysis showed better wound healing effects in the group using tropocollagen. Significant impact of collagen on the healing process was observed only after 8 weeks of application.

Tinnitus is a sensation of ringing in the ears in the absence of any physical source in the environment. Between 9–35% of adults experience some form of tinnitus. Common causes of tinnitus include noise, head injury, ototoxic substances, as well as disorders of blood and blood vessels. Vascular causes include: head—neck tumours, turbulent blood flow, problems with blood supply and inner ear cell damage. The aspect of rheology in terms of tinnitus has not been described yet. In the present study, which comprised 12 patients aged 30 to 74 years presenting with tinnitus, rheological properties of whole blood and plasma were assessed. All the subjects underwent audiological and neurological evaluation. The Quemada model was used to describe the variability of red blood cell shape, as well as their tendency to form aggregates. On the basis of the experimental study, statistically different results of haemorheological measurements were observed in the evaluated group in comparison to a reference group.

Introduction. The aim of the study was to evaluate the usefulness of the Clinical Direct Transmission System device and photographic medical documentation to assess the improvement in the skin of the face and hands before and after a one‑time CGF Harmony treatment.Material and methods. The study, after signing a voluntary informed consent, was attended by 3 patients of the Facial Aesthetics Clinic of the University Center of Dentistry and Specialist Medicine of the limited liability company. in Poznan. Once, in accordance with the procedure, a complex of stem cells and growth factors (CGF Harmony – in liquid and gel form) was administered to the area of the facial skin and the gel skin to the area of the dorsal surface of the hands. The observation period was 12 months, from the moment of the procedure, including control tests at several stages: before the procedure, immediately after administration, and approximately 6 and 12 months after the application.Results. The study showed no statistically significant differences in the surface tension of facial expressive muscles with a single application of CGF Harmony for most of the measurements.Conclusions. The analyzis of the photographic documentation and the subjective assessment of the patients, showed that the treatment turned out to be beneficial in terms of improving the quality of the facial skin and exceptionally beneficial in the area of the skin of the hands, which requires confirmation in further studies with a larger study group. There were no statistically significant changes in the facial expression muscles surface tension after the CGF Harmony procedure.