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Receptor binding activityReceptor binding activity X 0280 Aminoalkoxybiphenylnitriles as Histamine-3 Receptor Ligands. -Based on the preceding synthesis and testing of a series of related compounds, (I) is found to show high affinity for human histamine H 3 receptors coupled with other favorable physiological and pharmacodynamic properties. The results suggest that such compounds may have therapeutic potential in various human diseases. -(FAGHIH*, R.; DWIGHT, W.; VASUDEVAN, A.; DINGES, J.; CONNER, S. E.; ESBENSHADE, T. A.; BENNANI, Y. L.; HANCOCK, A. A.; Bioorg. Med. Chem. Lett. 12 (2002) 21, 3077-3079; Neurosci. Res., Global Pharm. Res. Dev., Abbott Lab., Abbott Park, IL 60031, USA; Eng.) -M. Bohle 09-210

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