Survival of pediatric AML remains poor despite maximized myelosuppressive therapy. The pneumocystis jiroveci pneumonia (PJP)-treating medication atovaquone (AQ) suppresses oxidative phosphorylation (OXPHOS) and reduces AML burden in patient-derived xenograft (PDX) mouse models, making it an ideal concomitant AML therapy. Poor palatability and limited product formulations have historically limited routine use of AQ in pediatric AML patients. Patients with de novo AML were enrolled at two hospitals. Daily AQ at established PJP dosing was combined with standard AML therapy, based on the Medical Research Council backbone. AQ compliance, adverse events (AEs), ease of administration score (scale: 1 (very difficult)-5 (very easy)) and blood/marrow pharmacokinetics (PK) were collected during Induction 1. Correlative studies assessed AQ-induced apoptosis and effects on OXPHOS. PDX models were treated with AQ. A total of 26 patients enrolled (ages 7.2 months–19.7 years, median 12 years); 24 were evaluable. A total of 14 (58%) and 19 (79%) evaluable patients achieved plasma concentrations above the known anti-leukemia concentration (>10 µM) by day 11 and at the end of Induction, respectively. Seven (29%) patients achieved adequate concentrations for PJP prophylaxis (>40 µM). Mean ease of administration score was 3.8. Correlative studies with AQ in patient samples demonstrated robust apoptosis, OXPHOS suppression, and prolonged survival in PDX models. Combining AQ with chemotherapy for AML appears feasible and safe in pediatric patients during Induction 1 and shows single-agent anti-leukemic effects in PDX models. AQ appears to be an ideal concomitant AML therapeutic but may require intra-patient dose adjustment to achieve concentrations sufficient for PJP prophylaxis.

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While research examining sexual violence in prison has increased over the past 15 years, relatively scant attention has been paid to rape supportive beliefs and the factors influencing inmate adherence to these beliefs. Given the demonstrated role from studies outside the prison context that rape supportive beliefs have on sexual violence, important parallels can be drawn from studying the inmate population. Importation and deprivation models have been used to explain how inmates adapt to prison life—whether attitudes and behaviors are imported from their lives outside prison or are developed in prison due to the conditions of incarceration. Using a sample of male and female inmates ( n = 875) from a large state prison system in the southern United States, the researchers explored the degree to which inmate rape supportive beliefs (IRSB) were influenced by variables indicative of importation or deprivation models of prison adaption. Findings revealed greater support for importation variables among both male and female inmates. With some variation, measures such as gender, age, ethnicity, and education were significant in explaining IRSB, similar to findings of studies on rape supportive beliefs among noninmate samples. Because these beliefs can manifest in problematic attitudes and behaviors among inmates, such as prison sexual violence and the underreporting of such violence, it is important that correctional administrators understand this relationship and take steps to lessen IRSB. Since IRSB largely correlate with factors unrelated to conditions of confinement, efforts to educate and sensitize inmates to prison sexual violence can replicate best practices based on populations outside of prisons.

Policing is often understood as a dangerous occupation. Subsequently, much research has examined police officer victimization. Scholarship is relatively scant, however, when focused on police dispatcher victimization. This gap in empirical discourse is concerning as these individuals serve an integral function for police and other emergency responders. Likewise, the actions taken by dispatchers impact the needs of citizens (e.g., crime victims, missing persons, etc.) and the actions taken by emergency services. Thus, the purpose of this chapter is focused on illustrating what is known about dispatcher victimization and how these occurrences impact these public servants both professionally and personally. Also discussed in the text are areas that need to be further explored by researchers and practitioners.