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We present novel parallel language constructs for the communication intensive part of a magnetic fusion simulation code. The focus of this work is the shift phase of charged particles of a tokamak simulation code in toroidal geometry. We introduce new hybrid PGAS/OpenMP implementations of highly optimized hybrid MPI/OpenMP based communication kernels. The hybrid PGAS implementations use an extension of standard hybrid programming techniques, enabling the distribution of high communication work loads of the underlying kernel among OpenMP threads. Building upon lightweight one-sided CAF (Fortran 2008) communication techniques, we also show the benefits of spreading out the communication over a longer period of time, resulting in a reduction of bandwidth requirements and a more sustained communication and computation overlap. Experiments on up to 130560 processors are conducted on the NERSC Hopper system, which is currently the largest HPC platform with hardware support for one-sided communication and show performance improvements of 52% at highest concurrency.

occurrence of occupational accidents was determined using multivariate logistic regression analyses. Multivariate analyses were adjusted for age, gender, marital status, children (yes/no), job title, multiple employers (yes/no) and the number of flights flown during [2005][2006][2007][2008] Conclusions The results of this study show that cumulative exposure to short-haul flights is associated with an increased risk for occupational accidents among cabin crew. This increased risk may be caused by the specific characteristics of short-haul flights, such as frequent customer service and a high time pressure. Future research should focus on the effects of alternation between different flight schedules and the influence of specific roster characteristics of short-haul schedules. Objective Here we present data comparing trends in surveillance of occupational diseases in France and the UK for allergic contact dermatitis attributed to chromate in cement (CDCr) and contact urticaria attributed to latex (UL) within the context of changes in legislation or of national actions to reduce exposure to allergens at these two countries workplace. Methods The time period for analysis was selected to coincide with the introduction of legislation or compensation in the UK and France (2005 for cement and 2004 for latex). Using the data of two nationwide occupational diseases reporting networks in UK and France (THOR and RNV3P respectively), we analysed the temporal trends of CDCr and of UL over the period 1998-2009. We calculated reporting odd ratio (ROR) with reference to period preceding the change of legislation for the causal agent (cement or latex) relative to time period after intervention, both for British and French data. The ROR compares the ratio of incident cases attributed to one specific allergen relative to all other causal agents, before and after the change in legislation. Background Since the demand for manufacturing flat panel display expands, we are ongoing an indium cohort study and followed up 310 indium exposure workers for 5 years to assess the changes on the lung effects. Methods We conducted a baseline epidemiologic survey in 14 indium related plants between 2003 and 2006. A 5-year followup study was conducted in 11 of these 14 initial plants between 2008 and 2011. Follow-up rate is 57.2% (310/542). Indium concentration in serum (In-S) was determined as an exposure parameter, and effects on the lungs were examined. Some potential confounders were also checked. All participates were classified into three categories, non-, current, and former exposure, according to occupational history of indium exposure. Results During the follow-up, intensive efforts for improvement of working environments were made in all 11 factories. In currently and formerly exposed workers, mean In-S and geometric means of interstitial biomarkers, KL-6 and SP-D, were significantly lower at follow-up than in the baseline study. In currently and formerly exposed workers, prevalence decreased by approximately 30% for KL-6 abnormalities but...

SUMMARYAutoantibodies to aminoacyl-tRNA synthetases are highly associated with myositis and detection is important in clinical diagnosis; however, current methods of screening limit its clinical utility. In the present study, alanyl-tRNA synthetase (PL-12) recombinant protein was obtained by immunological screening of a HeLa expression library and used in an ELISA with 22 anti-PL-12 sera, 200 autoimmune sera negative for PL-12 and 100 healthy individual sera. Sensitivity of the method was 95% (21/22) and specificity 100%. Mapping of the immunoreactive region was carried out using three anti-PL-12 sera and different recombinant protein-derived peptides. Results show that the same conformational epitope located within amino acids 730-951 of the PL-12 antigen outside the catalytic region was recognized by the three anti-PL-12 sera tested. We conclude that ELISA using recombinant protein is an effective and useful method for routine screening for anti-PL-12 autoantibodies.