Abstract. The influence of the serum calcium level and of the hormones regulating it, parathyroid hormone (PTH) and calcitonin (CT), on gastric secretion has been studied in the intact, parathyroidectomized (PTX) and thyro‐parathyroidectomized (TX‐PTX) chronic gastric fistula rat. The following test substances have been administered: CaCl2, bovine parathyroid hormone, Na2‐EDTA and porcine calcitonin. An increase of the serum calcium level caused a marked inhibition of gastric secretion, the parathyroid hormone did not show any effect without changes of the calcium level. Calcium decreases after EDTA as well as after calcitonin were also followed by a reduction of gastric secretion. There was no significant difference demonstrable between the intact, PTX‐and TX‐PTX‐animals. The calcitonin effect could be compensated by calcium substitution. A direct influence of PTH and CT on gastric secretion was not detectable; the hormones only exerted indirect effects via the changes of the serum calcium level they induced.

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