Karamunting (Rhodomyrtustomentosa (Aiton) Hassk.) is one of the most widespread plants in Sumaterawhich areknown to have traditionally used as wound and infection remedy. However, research on anti-inflammatory activity is limited. This study aimedto determine the effect of antiinflammatory of Karamunting (Rhodomyrtus tomentosa (Aiton) Hassk.) leaf extracts using acute rat model (carrageenan-induced rat paw oedema). Sodium diclofenac 4,5 mg.kg−1BW as standard anti-inflammatory drug, n-hexane, ethyl acetate, and ethanol of Karamunting (Rhodomyrtus tomentosa (Aiton) Hassk.) leaf extracts each dose 200 mg.kg−1BW were administered orally to 24 Wistar rats 1 h before induction oedema and compared with a negative control given Na CMC 1%. The mean percentage inhibition of paw volume of rats treated with sodium diclofenac was 64,82%, followed by n-hexane extract with 44,75%, ethyl acetat extract with 56,93%, and ethanol extract with 63,56%. All extract have similar antiinflammatory effect with sodium diclofenac (p>0,05). This result suggest that all Karamunting (Rhodomyrtus tomentosa (Aiton) Hassk.) leaf extracts have antiinflammatory properties comparable withstandard drugs.