Background: Globally, preterm birth and its complications have become major public health problems as it is a major determinant of neonatal morbidity and mortality with long-term adverse health consequences. It is the leading cause of neonatal and under-5 mortality globally. In Cameroon, especially in the South West Region, there is a paucity of data as concerns preterm birth and its related morbidities and outcome. Objectives: Our objective was to determine the prevalence and hospital outcome of preterm babies at the Regional Hospital Limbe. Methods: A hospital-based cross-sectional study with a retrospective review of files of preterm babies admitted in the neonatology unit from the 1st January 2017 to 31st December 2020. A structured data collection sheet was used to collect information from the files. Information obtained included independent variables (gestational age at birth, gender, birth weight, hospital complications during admission, treatment received and duration of admission) and dependent variables (dead or discharge). Relationship between dependent and independent variables was tested using Pearson Chi-square. Multivariate logistic regression was used to identify factors and independent associations. Result: Preterm admissions constituted 16.5% of the total admissions with a male to female ratio of 1:1.2. The common morbidities were respiratory distress 132(49.1%), hypothermia 72(26.8%), anaemia 70(26.0%), infection 65(24.2%) and jaundice 63(23.4%). The mortality rate was 31.8%. Preterm babies who had congenital malformation (AOR: 25.39;95%CI:1.80-356.38), apnoea (AOR:6.36;95%CI:1.49-27.09), respiratory distress (AOR:6.15;2.75-13.77) and anaemia (AOR:2.19;95%CI:1.07-4.50) were more likely to die compared to those who did not have these morbidities. Also, male preterm babies (AOR:2.72;95%CI:1.35-5.48) were more likely to die than their female counterparts. Conclusion: Preterm babies constituted a significant percentage of neonatal admissions at the Regional Hospital Limbe with the most frequent complications being respiratory distress, hypothermia, anaemia, infection and jaundice. The mortality rate was high, with more preterm babies dying from congenital malformation, apnoea, respiratory distress, and anaemia were strongly associated with mortality.

Objectives: Our study aimed to determine the relationship between the initial total prostate-specific antigen (PSA), PSA density, and aggressiveness of prostate cancer (PCa) based on the new Gleason grade group in the two specialized urology centers in Cameroon. Method: A seven-year retrospective study was conducted from January 2012 to December 2019. The study concerned all men diagnosed with PCa graded using the novel Gleason grade group. Data were analyzed descriptively and analytically using Statistical Package for Social Sciences (SPSS) version 20.0. Bivariate analysis was done to identify independent associations. Results: A total of 253 files were reviewed; fulfilling the inclusion criteria. The mean age of our study population was 66.62±8.288 years with the most affected age being those aged between 59-69 years. The commonest finding on DRE was a hard-craggy prostate (46.0%). The mean initial total PSA was 98.78 ng/dL ± 300.17 ng/mL, while the mean PSA density was 1.73 ± 5.94ng/mL². Gleason grade group 2 was the commonest grade (30.6%). There was a positive correlation between initial total PSA and Gleason grade group (r = 0.314 (p-value 0.000)), and between PSA density and Gleason grade group (r = 0.919 (p-value 0.000)). Initial total PSA and the Gleason grade groups were independently associated with the radiological tumour stage (p-value 0.000 and p-value 0.03 respectively). Conclusion: There is a positive correlation between initial total PSA, PSA density, and novel Gleason grade group. We, therefore, recommend that more attention should be placed on PSA density in pre-biopsy decisionmaking. This study enhances the stratification of therapeutic protocols for the management of PCa in Cameroon as well as across African Union member states.