Bone morphogenetic proteins (BMPs) are considered to have important regulatory roles in skeletal embryogenesis and bone healing. Recombinant human BMPs (rhBMPs) have been shown to heal critical size defects and promote spinal fusion. We studied the effects of rhBMP-2 in an absorbable collagen sponge (ACS) on bone healing in a large animal tibial fracture model. Bilateral closed tibial fractures were created in 16 skeletally mature goats and reduced and stabilized using external fixation. In each animal, one tibia received the study device (0.86 mg of rhBMP-2/ACS or buffer/ACS), and the contralateral fracture served as control. The device was implanted as a folded onlay or wrapped circumferentially around the fracture. Six weeks following fracture, the animals were sacrificed and the tibiae harvested for torsional testing and histomorphologic evaluation. Radiographs indicated increased callus at 3 weeks in the rhBMP-2/ACS treated tibiae. At 6 weeks, the rhBMP-2/ACS wrapped fractures had superior radiographic healing scores compared with buffer groups and controls. The rhBMP-2/ACS produced a significant increase in torsional toughness (p ؍ 0.02), and trends of increased torsional strength and stiffness ( p ؍ 0.09) compared with fracture controls. The device placed in a wrapped fashion around the fracture produced significantly tougher callus ( p ؍ 0.02) compared with the onlay application. Total callus new bone volume was significantly increased ( p ؍ 0.02) in the rhBMP-2/ACS fractures compared with buffer groups and controls regardless of the method of device application. The rhBMP-2/ACS did not alter the timing of onset of periosteal/ endosteal callus formation compared with controls. Neither the mineral apposition rates nor bone formation rates were affected by rhBMP-2/ACS treatment. The increased callus volume associated with rhBMP-2 treatment produced only moderate increases in strength and
External fixation of the canine spine has several potential advantages over internal fixation including minimal dissection for pin placement, the ability to span affected vertebrae with placement of implants distant from the site of injury, postoperative adjustability, and complete removal of implants after healing. This study supports the biomechanical stability ESSF of the canine lumbar spine. Further studies are indicated to evaluate zones of consistently safe and secure placement of pins and clinical efficacy.
Background: Acceptable amounts of malrotation after CRPP for pediatric supracondylar humerus fracture (SCHFx) have yet to be defined. This is an attempt to correlate radiographic parameters of a malrotated SCHFx with degrees of rotational malalignment to assist intraoperative assessment of reduction. Methods: 3D models of a left distal humerus were printed, simulating a transverse SCHFx with 5, 10, 15, 20, 25, and 30 degrees of malrotation. Four different scenarios were developed: (1) lateral cortical axis of rotation, (2) medial cortical axis of rotation, (3) centroid of the humerus longitudinal axis with the medial condyle rotated posteriorly, and (4) centroid of the humerus longitudinal axis with the medial condyle rotated anteriorly. Anteroposterior and lateral fluoroscopic views were taken with a consistent image profile. Five observers measured the amount of metaphyseal overhang on the lateral view and the width of the distal humerus just proximal to the fracture to establish amount of overhang as a percentage of distal humerus width. Regression analysis established “best fit” lines for the 4 scenarios. Ten observers used the observed characteristics of each type of malrotation and “best fit” lines to estimate axis and degrees of malrotation using the same fluoroscopy of the 24 models. Results: The intraclass correlation coefficient of reliability for percentage of metaphyseal overhang ranged from 0.775 to 0.987. Observers correctly predicted axis of malrotation in 76% and correctly predicted amount of malrotation in 75% of models. Conclusions: Estimation of axis of malrotation and degrees of malrotation within 5 degrees in SCHFx can be predicted in 75% of our 3D printed models.
Double-row rotator cuff repairs are becoming popular because of their ability to improve initial ultimate failure load for full-thickness rotator cuff tears, especially in middle-aged to elderly patients. We hypothesized a quasi-double-row repair using a combination of transosseous sutures, anchors, and double knots (TOAK technique) would exceed the clinically relevant 250-N load threshold and the initial mean ultimate failure loads of anchor-only and transosseous suture-only fixation. In simulated full-thickness supraspinatus tears in cadavers (mean age, 62 years; range, 50-77 years), failure loads of two repair techniques were compared with a TOAK repair using sutures and bioabsorbable anchors. Radiographic densitometry was conducted on all humeral heads. Testing was performed at 6 mm per minute in 18 bones in the following three groups (n = 6 per group): (1) transosseous suture-only with weave-type stitch and single-knot fixation; (2) anchor-only with horizontal mattress stitch and single-knot fixation; and (3) TOAK. The mean ultimate failure load was 238 N for the transosseous suture-only group and 215 N for the anchor-only group. Although the bones had lower density, TOAK specimens failed at 55% to 67% higher loads (mean, 404 N) than the other groups. These data support further evaluation of the TOAK technique for full-thickness supraspinatus tears in middle-aged to elderly patients.
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