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Poor gestational outcomes due to placental insufficiency can have lifelong consequences for mother and child. There is a need for better methods of diagnosis, and elemental metabolomics may provide a means to determine the risk of gestational disorders.This study used blood plasma samples collected at 36 weeks' gestation from women who later developed preeclampsia (n=38), or small-for-gestational age babies (n=91), along with matched controls (n=193). Multi-element analysis was conducted by inductively coupled plasma mass spectrometer (ICP-MS), allowing simultaneous measurement of 28 elements.Women who later developed PE, exhibited significantly increased concentrations of K, Rb and Ba. For SGA pregnancies, there was a significant in-crease in Cu and a decrease in As concentrations. Despite significant differences in single elements, the elemental profile of groups indicated no clustering of control, PE, or SGA samples. Positive predicative values correctly identified approximately 60% of SGA and 70% of PE samples. This is the first-time elemental metabolomics has been used to predict SGA and PE at 36 weeks. Though significant changes were identified, routine clinical use may be limited but may contribute to a multi marker test. Future analysis should include other biomarkers, metabolic data or clinical measurements made throughout gestation.

The accurate measurement of suspended sediment (<200 μm) in aquatic environments is essential to understand and effectively manage changes to sediment, nutrient, and contaminant concentrations on both temporal and spatial scales. Commonly used sampling techniques for suspended sediment either lack the ability to accurately measure sediment concentration (e.g., passive sediment samplers) or are too expensive to deploy in sufficient number to provide landscape‐scale information (e.g., automated discrete samplers). Here, we evaluate a time‐integrated suspended sediment sampling technique, the pumped active suspended sediment (PASS) sampler, which collects a sample that can be used for the accurate measurement of time‐weighted average (TWA) suspended sediment concentration and sediment particle size distribution. The sampler was evaluated against an established passive time‐integrated suspended sediment sampling technique (i.e., Phillips sampler) and the standard discrete sampling method (i.e., manual discrete sampling). The PASS sampler collected a sample representative of TWA suspended sediment concentration and particle size distribution of a control sediment under laboratory conditions. Field application of the PASS sampler showed that it collected a representative TWA suspended sediment concentration and particle size distribution during high flow events in an urban stream. The particle size distribution of sediment collected by the PASS and Phillips samplers were comparable and the TWA suspended sediment concentration of the samples collected using the PASS and discrete sampling techniques agreed well, differing by only 4% and 6% for two different high flow events. We should note that the current configuration of the PASS sampler does not provide a flow‐weighted measurement and, therefore, is not suitable for the determination of sediment loads. The PASS sampler is a simple, inexpensive, and robust in situ sampling technique for the accurate measurement of TWA suspended sediment concentration and particle size distribution.

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