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A number of 9-(3-deoxy-3-methylamino-/?-D-ribofuranosyl)-6-substituted purines have been prepared with the 6 substituent being amino, dimethylamino (2), oxygen, and sulfur (31). Compound 31 is the first example of a nucleoside with purine-6-thione bonded to an amino sugar. Compound 2 was further substituted at the S'-methylamino position with a p-methoxyphenyl-L-alanyl group to give 3'-iV-methylpuromycin (2a). Eschweiler-Clarke methylation, carried out for the first time on a nucleoside, of the 6-dimethylaminopurine nucleoside 2 gave the 3'-deoxy-3'-dimethylamino-D-ribofuranose derivative 3. The key intermediate required for the (9) (a) B. R.

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