The DeltaGAG deletion mutation in DYT1, causing a loss of a glutamic acid near the carboxyl terminus of torsinA protein (torsinADeltaE), is dominantly inherited and tends to result in a severe generalized form of dystonia with childhood onset. We have used a yeast two-hybrid interaction assay to examine torsinA and its mutant torsinADeltaE interactions. Our data showed that torsinA monomers are capable of interacting with themselves and that mutant torsinADeltaE fails to interact with itself or with torsinA. We also demonstrated that purified torsinA protein is an ATPase, which forms a multimeric complex in vitro and that the DeltaGAG mutation disrupts the formation of multimeric complex and decreases torsinA's ATPase activity.

IncreTable is a mixed-reality tabletop game inspired by The Incredible Machine. Users can combine real and virtual game pieces in order to solve puzzles in the game. Game actions include placing virtual domino blocks with digital pens, controlling a virtual car by modifying the virtual terrain through a depth camera interface, and controlling real robots to topple over real and virtual dominoes.