The colorectal cancer is one of most frequent neoplasia in adult population. Since was described the adenoma-carcinoma sequence for the first time in 1978, the elucidation of the molecular mechanisms involved in the pathogenesis of colorectal cancer became studied. The study of colorectal cancer has been one of the most important elements for understanding the mechanisms involved in the genesis of malignant neoplasms. Several genes, like DCC, APC, p53 were identified as participants of the adenoma-carcinoma. The annexin A1 protein (ANXA1) is related with some types of tumor and its study in colorectal cancer in scientific literature is been done, but discreetly yet. The increasing advancement in molecular biology research have contributes for understanding the carcinogenesis, with the possibility of detecting earlier pre-malignant lesions and a proper diagnosis, more over it allow the development an efficient therapy.