The Nearctic region is located on the North American plate. However, its tectonic history is related to convergence with other plates, which has promoted a complex topography. This complexity should be reflected by the distributional patterns of the biota. We used track analysis with 574 species of mammals to identify generalized tracks and panbiogeographic nodes in the Nearctic region and to propose an updated point of view of complex areas and their boundaries in North America. Seven generalized tracks with nested patterns (California, Columbia Plateau, Mesoamerican, Mexican Plateau, Neotropic, Southern Rocky Mountains, and Western Coast of USA) were identified using a parsimony analysis of endemicity with progressive character elimination. Nine panbiogeographic nodes were identified at the intersections of the generalized tracks, all of which were located in the Sierra of Chiapas and Central America physical features. A total of 192 nodes were identified for the nested patterns, located in only eight physical features. Our analysis revealed evolutionary patterns in generalized tracks, and the panbiogeographic nodes predicted areas with high evolutionary–geologic complexity, shared by other taxonomic groups.