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The major alkaloid of the meadow saffron is colchicine, which displays remarkable antimitotic activity and has long been used in the treatment of acute gout and is currently being tested against a broad variety of other diseases. In a remarkable Rh‐catalyzed domino transformation, the complete carbon skeleton of this important alkaloid is assembled with high efficiency (see scheme). TBS=tert‐butyldimethylsilyl, TMS=trimethylsilyl.

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