This study shows that severely obese, non-diabetic patients who had pronounced weight loss after bariatric surgery had an overall improvement in brachial flow-mediated dilation, CIMT, high-sensitivity CRP, and glucose and lipid metabolism. The best responses of the brachial flow-mediated dilation after surgery were observed in non-smokers and in younger subjects.

BackgroundObesity is a worldwide disease related to genetic, environmental, and behavioral factors, and it is associated with high rates of morbidity and mortality. Recently, obesity has been characterized by a low-grade inflammatory state known as inflammome indicated by chronic increases in circulating concentrations of inflammatory markers. The purpose of this study was to evaluate the effect of weight loss induced by surgery for obesity and weight-related diseases on pro-inflammatory cytokine (TNF-α) and anti-inflammatory adipokine (adiponectin) levels, and on an adipose-derived hormone (leptin) in severely obese subjects.MethodsThis randomized, controlled trial involved 55 severe obese patients (50 women, age 18–63 years, and body mass index of 35.7–63 kg/m2) who underwent bariatric surgery (BS). Patients with a BMI > 65 kg/m2 and clinical and mental instability, or significant and unrealistic expectations of surgery were excluded. Blood samples were collected during the fasting period to analyze tumor necrosis factor alpha (TNF-α), adiponectin, and leptin levels by enzyme-linked immunosorbent assay.ResultsAt baseline, no significant difference was observed in the anthropometric, demographic, clinical characteristics and biochemistry and inflammatory markers between the control group (CG) and bariatric surgery group (BSG). The same finding was also observed when we compared the baseline variables to those at the 6-month follow-up in the CG. However, the same variables in the BSG group were significantly different between baseline and the 6-month follow-up after BS.ConclusionsWeight loss induced by surgery for obesity and weight-related diseases reduced the inflammome state in severely obese patients.

BackgroundThe increasing prevalence of obesity in both developed and developing countries is one of the most serious public health problems and has led to a global epidemic. Obesity is one of the greatest risk factors of obstructive sleep apnea (OSA), which is found in 60 to 70% of obese patients mainly due to the buildup of fat tissue in the upper portion of the thorax and neck. The aim of the present randomized clinical trial is to assess daytime sleepiness, sleep architecture and pulmonary function in patients with severe obesity before and after bariatric surgery.MethodsThis randomized, controlled trial, was designed, conducted, and reported in accordance with the standards of The CONSORT (Consolidated Standards of Reporting Trials) Statement. Patients were divided into a bariatric surgery group and control group. The clinical evaluation was performed at the Sleep Laboratory of the Nove de JulhoUniversity (Sao Paulo, Brazil) and consisted of the collection of clinical data, weight, height, body mass index (BMI), measurements of neck and abdomen circumferences, spirometry, maximum ventilatory pressure measurements, standard overnight polysomnography (PSG) and the administration of the Berlin Questionnaire and Epworth Sleepiness Scale.ResultsFifty-two patients participated in the present study and performed PSG. Out of these, 16 underwent bariatric surgery. After surgery, mean BMI decreased from 48.15 ± 8.58 to 36.91 ± 6.67 Kg/m2. Significant differences were found between the preoperative and postoperative periods regarding neck (p < 0.001) and waist circumference (p < 0.001), maximum inspiratory pressure (p = 0.002 and p = 0.004) and maximum expiratory pressure (p = 0.001 and p = 0.002) for women and men, respectively, as well as sleep stage N3 (p < 0.001), REM sleep (p = 0.049) and the apnea-hypopnea index (p = 0.008).ConclusionsBariatric surgery effectively reduces neck and waist circumference, increases maximum ventilatory pressures, enhances sleep architecture and reduces respiratory sleep disorders, specifically obstructive sleep apnea, in patients with severe obesity.Trial registrationThe protocol for this study was registered with the World Health Organization (Universal Trial Number: U1111-1121-8873) and Brazilian Registry of Clinical Trials – ReBEC (RBR-9k9hhv).

RESUMOOBJETIVO. Avaliar fatores preditivos de colelitíase em obesos mórbidos submetidos a gastroplastia com reconstrução em Y de Roux. MÉTODOS. Estudou-se um grupo de pacientes obesos inscritos no programa para tratamento cirúrgico da obesidade mórbida do Departamento de Cirurgia da Faculdade de Ciências Médicas da Santa Casa de São Paulo. Os critérios de exclusão foram: pacientes colecistectomizados previamente, pacientes com diagnóstico de colelitíase no pré-operatório e casos em que a ultra-sonografia era duvidosa em relação à presença de cálculos biliares. Foram operados 160 pacientes, sendo 29 com colecistectomia prévia, 23 com litíase biliar pré-peratória, 5 com ultrassonografia duvidosa e 103 com vesícula biliar normal ao ultra-som de abdome. RESULTADOS. Os resultados mostraram que 48 (46,6%) pacientes desenvolveram colelitíase, sendo 22 sintomáticos. Quando comparamos os pacientes com e sem colelitíase, não observamos diferenças significativas em relação à idade, sexo e peso pré-operatório. O índice de massa corpórea, os níveis séricos de triglicérides, o colesterol total e suas frações VLDLcolesterol e LDL-colesterol foram superiores no grupo que desenvolveu colelitíase em relação aos pacientes sem cálculos, sendo esta diferença estatisticamente significativa. A porcentagem de perda de peso no 6º e 12º mês pós-operatório foi significativamente superior nos pacientes que desenvolveram cálculos biliares. CONCLUSÃO. O estudo permite concluir que índice de massa corpórea, os níveis de triglicérides, colesterol total e suas frações LDL e VLDL são fatores preditivos de colelitíase após gastroplastia com reconstrução em Y de Roux. UNITERMOS INTRODUÇÃOA doença biliar é comum nos obesos mórbidos, sendo a obesidade o maior fator de risco para o desenvolvimento de cálculos de colesterol 28 . Cerca de 25% a 45% desta população apresenta colelitíase, sendo realizadas cerca de 750.000 colecistectomias por ano nos Estados Unidos, acarretando um custo de 8 a 10 bilhões de dólares. Quando somadas as colecistectomias prévias e a colelitíase diagnosticada no pré-operatório de obesos submetidos a cirurgia bariátrica esse valor varia de 28% a 45% 1-5 . A alta incidência de doença da vesícula biliar em obesos foi demonstrada por diversos autores, merecendo destaque Dittrick et al. 5 , que compararam doenças da vesícula biliar de obesos submetidos a cirurgia bariátrica e colelistectomia profilática em relação à vesícula biliar de doadores de órgãos. Seus resultados mostraram uma incidência de doença biliar em 79% dos obesos e em apenas 28% do grupo controle 5 . Na Itália, um estudo epidemiológico revelou uma incidência de 17% de cálculos assintomáticos em 4.751 indivíduos submetidos à ultra-sonografia 6 . No Chile, que apresenta a segunda maior prevalência no mundo, estudos realizados após necropsias mostraram que mais de 50% das mulheres adultas tinham colelitíase 7 .Foi evidenciada uma maior incidência de colelitíase em mulheres com IMC maior do que 30 kg/ m 2 do que em mulheres com IMC menor do que 25 kg/ m 2 . Quando est...