Brexit will be a significant event, the outcomes and consequences of which are impossible to predict fully. However, it is safe to say that things will change, some at a cost, while hopefully others will be made to work to the advantage of the UK. Dentistry will not be immune to Brexit-related changes. Indeed, with the anticipated ‘hard’ Brexit, the profession and the provision of oral healthcare in the UK will face a number of changes, some of which will pose challenges but hopefully also provide not-to-be-missed opportunities for the profession. A failure to respond positively to Brexit developments may disadvantage us all.