Objective: To explore the predictive factors on fatigue among pulmonary tuberculosis patients receiving anti-tuberculosis drugs.Methods: This study is a predictive correlational research designed. The sample was comprised of 125 patients at the out-patient department, a tertiary hospital in Bangkok setting. The data were collected between January to February 2020. The questionnaires included mini-cognitive assessment instrument (Mini-Cog); the demographic characteristics questionnaire; Piper fatigue scale-12 (PFS-12); Nutrition alert form (NAF); the Pittsburgh sleep quality index (PSQI); and the Center for epidemiologic studies depression scale (CES-D). All data were analyzed by using descriptive statistics and multiple regression analysis.Results: The sample had a mean age of 58.45 years (SD = 15.374) of which 60.8% were males. Overall, the mean score of fatigue was a moderate level (Mean = 4.90, SD = 2.455). From the multiple regression analysis, age, nutritional status, sleep quality, and depression could explain the variances on fatigue in the sample group as 52.5% (R2 = .525, F = 33.119, p < .001). Nutritional status, sleep quality, and depression are the variables found to be capable in predicting fatigue of pulmonary tuberculosis patients with statistical significance (β = .316, p < .001, β = .226, p < .05 and β = .340, p < .001). Conclusion: Nutritional status, sleep quality, and depression could affect fatigue. Healthcare teams should assess patients to prevent and manage the aforementioned symptoms to reduce suffering from fatigue and a better quality of life.