of benefits and harms Significant reductions in treatment discontinuation, overall rate of hypersensitivity, and rate of fever were detected for desensitization protocols in adults. The meta-analyses did not show a difference between the two strategies in terms of cutaneous adverse reactions, serious adverse reactions, or adverse reactions requiring hospitalization. Overall completeness and applicability of evidence5 Cotrimoxazole for prophylaxis or treatment of opportunistic infections of HIV/AIDS in patients with previous history of hypersensitivity to cotrimoxazole (Review)