No abstract

Background Neonatal jaundice is one of the most common problems in newborns. Phototherapy is the most widespread treatment for lowering bilirubin concentration in neonates. Phototherapy may be more effective if the light source is placed closer to the neonate.Objective To compare the effectiveness of phototherapy with a 20 cm distance between the light source and the neonate vs a 40 cm distance for decreasing serum bilirubin concentrationMethods An open, randomized, controlled trial was conducted at H. Adam Malik and Pirngadi Hospitals in Medan from August 2009 to March 2010. Subjects were divided into two groups. One group (n=30) received phototherapy at a distance of 20 cm between the light source and the neonate, while the other group (n=30) received phototherapy at a distance of 40 cm. The inclusion criteria in the study were newborns presenting with neonatal jaundice in their first week of life. Serum bilirubin levels were measured at baseline, as well as after 12 hours and 24 hours of phototherapy.Results The mean total bilirubin levels of the 20 cm and 40 cm groups at baseline were 18.8 (SD 1.73) mg/dL and 17.7 (SD 1.46) mg/dL, respectively, not significantly different. After 24 hours of phototherapy, the mean decreases in total serum bilirubin levels of the 20 cm and 40 cm groups were significantly different with 7.6 (SD 1.01) mg/dL and 2.0 (SD 0.83) mg/dL, respectively, (P<0.05).Conclusion Phototherapy with a 20 cm distance between the light source and the neonate is more effective than a 40 cm distance for decreasing bilirubin levels at 24 hours in newborns with hyperbilirubinemia.

Background Malnutrition in hospitalized children has negative impact on morbidity, mortality, length of stay, and health-care cost. A simple screening tool is needed to detect hospital malnutrition risk in children. Objective To compare the level of agreement of the Screening Tool for Malnutrition in Pediatrics (STAMP) and Pediatric Nutritional Risk Score (PNRS) with anthropometric measurements, as screening tools for hospital malnutrition in children. Methods A cross-sectional study was conducted from February to July 2014 in the Pediatric and Surgery Wards at H. Adam Malik Hospital, Medan, North Sumatera. Inclusion criteria were children aged 2 to 18 years who were hospitalized for more than 72 hours. Subjects were screened using STAMP and PNRS, and underwent anthropometric measurement on admission. The weight measurements were repeated on the 3 rd and 7t h days, and just before discharge. The STAMP and PNRS results were compared in terms of level of agreement with anthropometric measurements. Data were analyzed by Kappa value and Spearman's correlation test. Results A total of 127 children were screened with both instruments. The PNRS had slight agreement with hospital malnutrition prevalence (K=0.175; P=0.028), while STAMP had not (K=0.080; P=0.193). Both screening tools had weak positive correlations with length of stay, but the correlation was stronger for PNRS than for STAMP (r=0.218; P=0.014 vs. r=0.188; P=0.034, respectively). The prevalence of hospital malnutrition was 40.9%. Conclusion The PNRS screening tool has slight agreement with anthropometric measurement for identifying hospital malnutrition risk in children. [Paediatr Indones. 2017;57:117-23; doi: http:// dx

BACKGROUND: Many studies have shown low Vitamin-D level as a risk factor for autoimmune diseases, especially multiple sclerosis and thyroid disease. Graves’ disease (GD) is an autoimmune disease caused by autoantibodies that stimulate thyroid-stimulating hormone (TSH) receptors by increasing thyroid hormone synthesis and secretion. Several studies report that many patients with autoimmune thyroid disease including GD have low Vitamin-D status. AIM: The objective of the study was to evaluate the effect of Vitamin-D supplement on GD patients on improvement in thyroid hormone levels. METHODS: Open random clinical trial was conducted in GD patients to determine changes in thyroid hormone to achieving normal levels between those receiving methimazole plus Vitamin-D supplementation compared with those who only received methimazole. Patients were checked for TSH receptor antibody, thyroid profile and Vitamin-D level before treatment and rechecked for thyroid profile and Vitamin-D level 3 months after treatment. t-test used to compare the drug efficacy (p < 0.05) in two groups. RESULTS: From 25 children with GD accompanied by Vitamin-D deficiency with an average value of Vitamin-D was 16 ng/mL. GD children who receive methimazole with Vitamin-D supplement had elevated TSH levels in the 3rd month of therapy that was significantly different compared to GD children who received methimazole only (p = 0.00), and the increase of TSH was also followed by an increase in Vitamin-D levels. CONCLUSION: All children with GD had Vitamin D deficiency, and the addition of Vitamin-D supplement to GD therapy would improve TSH faster than children who did not receive Vitamin-D supplement.

Background: Nutritional status is believed to affect the immune system and parasite density in children diagnosed with malaria from Plasmodium vivax infection. It is known that nutritional status could facilitate the growth of protective immune response towards malaria antigen, but some studies have shown that poor nutrition could cause clinical complications and lead to severe malaria. There have also been different reports on the relationship between nutritional status and parasite density. Objectives: This study aimed to examine the association between nutritional status and parasite density in children with vivax malaria in Kualuh Leidong area. Methods: This cross-sectional study was conducted from October 2019 to January 2020 in Kualuh Leidong to investigate 48 children aged between 2 - 18 and diagnosed with vivax malaria. The nutritional status of children with fever and positive Plasmodium vivax confirmed by microscopic examination were evaluated. Parasite density was determined in order to assess the severity of the infection. A non-parametric test was performed to examine the association between these two conditions. Results: There was a significant association (P = 0.032) between sexual parasite density and nutritional status. A post hoc test showed that overweight or mild malnutrition significantly correlated (P = 0.029) with high sexual parasite density. However, no significant association was found between nutritional status and asexual parasite density (P = 0.222).