Among four species of Shigella, Shigella dysentriae (S. dysenteriae) is the most virulent species and often isolated from cases of shigellosis. The initial step in the development of colonization by S. dysenteriae is its ability to adhere toward mucosal surface by using adhesion molecule. Adhesion proteins of bacteria found in the pili and cell wall was evident as the hemagglutinin protein (HA). Until now there is no effective vaccine to Shigellosis in accordance with the expectations formalized by the WHO. This study aimed to prove that HA protein subunit pili with MW 49.8 kDa of S. dysenteriae antibody can inhibit the adhesion of S. dysenteriae on enterocyte of mice by using dose response and immunocytochemistry test (IT). Dose response method with the implementation of dose dilution of 1/400,
Penyakit Ginjal Kronik (PGK) adalah kondisi irreversible dimana fungsi ginjal menurun dari waktu ke waktu. Kondisi fungsi ginjal memburuk, kemampuan untuk memproduksi erythropoietin yang memadai terganggu, sehingga terjadi anemia. Tujuan penelitian ini untuk mengetahui perbedaan kadar Hb pre dengan post Hemodialisis pada pasien penyakit ginjal kronik di RSU “KH” Batu. Jenis penelitian yang digunakan adalah deskriptif kuantitatif yang menggunakan desain cross sectional dengan menggunakan teknik Quota Sampling. Sampel yang dipilih adalah 20 responden yang memenuhi kriteria inklusi. Data diambil dengan cara melakukan pengecekkan kadar Hb secara langsung pada responden. Uji statistik menggunakan uji t-test berpasangan didapatkan nilai rerata kadar Hb pre Hemodialisis adalah 7,38 dan rerata kadar Hb post Hemodialisis adalah 7,10. Hasil uji t-test berpasangan didapatkan nilai p=0,039 (p<0,05). Hasil penelitian ini menunjukkan bahwa terdapat perbedaan yang bermakna antara kadar Hb pre dengan post Hemodialisis pada pasien penyakit ginjal kronik, dimana kadar Hb post Hemodialisis lebih rendah daripada kadar Hb pre Hemodialisis. Hal tersebut dikarenakan sejumlah kecil darah biasanya tertinggal di dalam dialiser. Hal ini dapat menjadi sumber kekurangan zat besi dari waktu ke waktu, sehingga menimbulkan anemia. Oleh karena itu, perlu dilakukan penelitian tentang penanganan anemia pada pasien Penyakit Ginjal Kronik yang menjalani terapi Hemodialisis.
Incidence of kidney failure in Indonesia has increased by 20% annually, an estimated 70,000 people in 2011, 4,000-5,000 people are detected with end-stages renal failure and undergoing hemodialysis. The hemodialysis process causes some blood trapped or left in the hemodialysis device, some red blood cells are damaged and folic acid decreases. The aims of this study was to know the difference of hemoglobin (Hb) profile in End Stages Renal Disease (ESRD) patients based on duration of hemodialysis at RS "S" Malang. The research method used a comparative design with a sample of 100 respondents. Anova test showed the difference of Hb level profile in ESRD patients based on duration of hemodialysis from 1 year up to 10 years (p = 0,03; α = 0,05), which means that the longer the hemodialysis then the Hb level decreases. Anemia is a complication of ESRD, the decrease in Hb resulting from disruption of the production of the hormone erythropoetin, in addition hemodialysis process also exacerbates the degree of anemia where some red blood cells trapped in hemodialysis, red blood cells are damaged, and folic acid decreased due to dissolved in fluid dialysis. Furthermore, it is necessary to examine related factors that cause the decrease in Hb in patientss with ESRD with hemodialysis therapy both intrinsic and extrinsic factors. PENDAHULUANEnd Stage Renal Disease (ESRD) merupakan suatu proses kerusakan sel-sel ginjal dengan rentang waktu lebih dari 3 bulan. ESRD dapat menimbulkan gejala berupa laju filtrasi glomerular di bawah 60 mL/men/1.73 m2, atau di atas nilai tersebut namun disertai dengan kelainan sedimen urin. Proses perjalanan penyakit dari ESRD disebabkan oleh berbagai etiologi yang secara progresif menurunkan fungsi dari ginjal, sehingga lama-kelamaan ginjal akan mengalami kehilangan fungsinya yang disebut dengan gagal ginjal. Kerusakan sel ginjal bersifat PROSIDING SEMINAR NASIONAL 2018 Peran dan Tanggung Jawab Tenaga Kesehatan dalam Mendukung Program Kesehatan
Kendaraan bermotor merupakan penyebab utama polusi udarah di perkotaan yang menyumbang sekitar 71% pencemar oksida nitrogen (NOX), 15% pencemar oksida sulfur (SOx), dan 70% pencemar partikulat (PM10) sehingga Para pekerja memiliki resiko tinggi terpapar polusi udarah karena setiap hari mereka bekerja di tempat yang berhubungan dengan asap kendaraan bermotor.Dalam asap kendaraan bermotor mengandung zat-zat toksin yang dapat mempengarhui Hb ,sebab Kadar Hb berfungsi mengantar oksigen ke seluruh tubuh. Penelitian ini bertujuan untuk mengetauhi pengaruh lama kerja terhadap kadar Hb pada pekerja yang terpapar asap kendaraan bermotor . Penelitian ini menggunakan desain Studi literature dengan disintesis menggunakan metode naratif. Kriteria artikel/jurnal yang digunakan adalah yang diterbitkan tahun 2015-2020 dan artikel/jurnal ini dikumpulkan dengan menggunakan mesin pencari seperti Scient Direct, e-resorces, proquest dan Scholar. Hasil penelitian ini menunjukan bahwa zat yang terdapat pada asap kendaraan bermotor memiliki pengaruh terhadap kadar Hb dan semakin lama terpapar degan lama kerja 3 tahun dengan masa kerja 3-9 jam/hari beresiko tinggi mengalami penurunan kadar Hb hasil penelitian menurut 16 jurnal yang telah direview. Disimpulkan bawah ada pengaruh lama kerja terhadap kadar hemoglobin pada pekerja yang terpapar asap kendaraan bermotor.
The prevalence of chronic kidney disease in Indonesia is increasing, especially in Saiful Anwar Hospital Malang, because the patients must undergo hemodyalisis therapy. Hemodialysis therapy has an effect to induce xerosis. Untreated xerosis will cause pruritus. Therefore this condition needs to use moisturizer to prevent pruritus like aloe vera extract. The purpose of this research was to determine the effect of using aloe vera extract on the treatment of the skin of patients with chronic kidney failure. The research method was true experimental research and used simple random sampling technique to recruit 25 respondents. Aloe vera extract was used by rubbing it onto the skin with xerosis and assessment was conducted in the first, second and third week. The analysis of this research used the Kruskal-Wallis test and Linear Regression. The result of different test was p = 0.001 or α <0.01 showed that there was significant differences between groups of independent variables. The R ^ 2 value was 69% , it mean that aloe vera extract had an effect as much as 69% of improvement in skin conditions of xerosis patients and 31 % was influenced by other factors besides extract aloe vera. The results showed that aloe vera extract with 75% concentration gave the most effective treatment for xerosis patients. Therefore, aloe vera could be a therapy for xerosis as a management of independent nursing care with nursing problems of skin integrity disorders.
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